AOPs

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Showing 526 to 550 of 589 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
81 Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone BY-SA None
80 Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure Carlie LaLone BY-SA 559: Activation, Nicotinic acetylcholine receptor
79 Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure Carlie LaLone BY-SA 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony
78 Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 Carlie LaLone BY-SA 559: Activation, Nicotinic acetylcholine receptor
77 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 Carlie LaLone BY-SA 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony
74 Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis Undefined BY-SA 662: Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis 543: Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis
73 Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity Undefined BY-SA 526: Inhibition, Inhibition of Dopamine-beta-hydroxylase 527: Decreased, Decreased fecundity
72 Epigenetic modification of PPARG leading to adipogenesis Michelle Angrish BY-SA 1447: obesity
71 Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation Undefined BY-SA 650: Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid 520: Decreased sperm quantity or quality in the adult, Decreased fertility
70 Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell Undefined BY-SA 640: Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell 520: Decreased sperm quantity or quality in the adult, Decreased fertility
69 Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell Undefined BY-SA 646: Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis
68 Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome Undefined BY-SA 661: Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome 505: Decreased sperm quantity / quality in the adult, Decreased fertility
67 Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis Undefined BY-SA 505: Decreased sperm quantity / quality in the adult, Decreased fertility
66 Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis Undefined BY-SA 505: Decreased sperm quantity / quality in the adult, Decreased fertility
64 Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility Undefined BY-SA 494: Glucocorticoid Receptor Agonist, Activation 406: decreased, Fertility
63 Cyclooxygenase inhibition leading to reproductive dysfunction Dalma Martinovic-Weigelt BY-SA 79: Inhibition, Cyclooxygenase activity
62 AKT2 activation leading to hepatic steatosis Michelle Angrish BY-SA 486: systemic inflammation leading to hepatic steatosis 459: Increase, Liver steatosis
61 NFE2L2/FXR activation leading to hepatic steatosis Michelle Angrish BY-SA 459: Increase, Liver steatosis
60 NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis Michelle Angrish BY-SA 245: Activation, PXR/SXR 459: Increase, Liver steatosis
59 HNF4alpha suppression leading to hepatic steatosis Michelle Angrish BY-SA 461: Suppression, HNF4alpha None
58 NR1I3 (CAR) suppression leading to hepatic steatosis Michelle Angrish BY-SA 459: Increase, Liver steatosis
57 AhR activation leading to hepatic steatosis Michelle Angrish BY-SA 18: Activation, AhR 459: Increase, Liver steatosis
54 Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment Anna Price BY-SA 424: Inhibition, Na+/I- symporter (NIS) 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.28
53 ER agonism leading to reduced survival due to renal failure Undefined BY-SA 111: Agonism, Estrogen receptor None
52 ER agonism leading to skewed sex ratios due to altered sexual differentiation in males Undefined BY-SA 111: Agonism, Estrogen receptor 417: skewed, sex ratio