AOPs

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Showing 26 to 26 of 26 AOPs in Title Search Results

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ID Title Point of Contact License MIE AO OECD Status OECD Project
636 Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS) Shihori Tanabe All rights reserved 1115: Increase, Reactive oxygen species 2416: human amyotrophic lateral sclerosis (ALS)

AOP Fulltext Search Results

Showing 1 to 25 of 30 Fulltext Results
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ID Title Point of Contact License MIE AO OECD Status OECD Project
149 Peptide Oxidation Leading to Hypertension Frazer Lowe BY-SA 209: Peptide Oxidation 952: Hypertension Under Development 1.50
207 NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans Jinhee Choi All rights reserved 1174: Activation, NADPH Oxidase 1277: Reproductive failure
213 Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) Lyle Burgoon Open for adoption 1490: Inhibition, Fatty Acid Beta Oxidation 1489: Increase, Steatohepatitis
220 Cyp2E1 Activation Leading to Liver Cancer Francina Webster BY-SA 1391: Activation of Cyp2E1 1395: Liver Cancer WPHA/WNT Endorsed 1.24
266 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
267 Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
268 Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
282 Adverse outcome pathway on photochemical toxicity initiated by light exposure Satomi Onoue BY-SA 1115: Increase, Reactive oxygen species 1599: Inflamatory events in light-exposed tissues Under Review 1.49
298 Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer Shihori Tanabe BY-SA 1115: Increase, Reactive oxygen species 1651: Treatment-resistant gastric cancer Under Review 1.58
324 Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and cell death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
386 Deposition of ionizing energy leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
387 Deposition of ionising energy leading to population decline via mitochondrial dysfunction Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
396 Deposition of ionizing energy leads to population decline via impaired meiosis Erica Maremonti All rights reserved 1550: Deposition of Ionizing Energy
406 SARS-CoV-2 infection leading to hyperinflammation Hasmik Yepiskoposyan All rights reserved 1739: Binding to ACE2 1868: Hyperinflammation
413 Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure Carmel Mothersill BY-SA 926: Oxidation, Glutathione (To be considered with MIE) 351: Increased Mortality
450 Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality SAROJ AMAR BY-SA 12: Acetylcholinesterase (AchE) Inhibition
451 Interaction with lung resident cell membrane components leads to lung cancer Penny Nymark BY-SA 1495: Substance interaction with the lung resident cell membrane components 1670: Lung cancer
457 Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine Simon Thomas Open for adoption 2118: Succinate dehydrogenase, inhibited 2119: Increase, Insulin resistance
462 Activation of reactive oxygen species leading the atherosclerosis Hiromi Ohara BY-SA 1115: Increase, Reactive oxygen species None
505 Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway John Frisch BY-SA 1115: Increase, Reactive oxygen species 885: Increase, Cancer
507 Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway Yanhong Wei All rights reserved 1417: NFE2/Nrf2 repression 2161: Increase, Vascular disrupting effects
511 The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects Yanhong Wei All rights reserved 1115: Increase, Reactive oxygen species 2161: Increase, Vascular disrupting effects
513 Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway John Frisch BY-SA 1115: Increase, Reactive oxygen species 885: Increase, Cancer
534 Succinate dehydrogenase (SDH) inhibition leads to oxidative stress Xavier COUMOUL All rights reserved 2118: Succinate dehydrogenase, inhibited 1392: Increase, Oxidative Stress
538 Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways Yanhong Wei All rights reserved None 2161: Increase, Vascular disrupting effects