AOP-Wiki

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All Key Events

Showing 651 to 675 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1775	Increase, Oocyte apoptosis Short Name Increase, Oocyte apoptosis	0	Cellular	Apr 30, 2020	Apr 30, 2020	5 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 338: DNA methyltransferase inhibition leading to population decline (3) 396: Deposition of ionizing energy leads to population decline via impaired meiosis 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
1774	Increase, Caspase transcription Short Name Increase, Casp transcription	0	Molecular	Apr 30, 2020	Apr 30, 2020	4 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 338: DNA methyltransferase inhibition leading to population decline (3) 339: DNA methyltransferase inhibition leading to population decline (4)
1773	Decrease, Global DNA methylation Short Name Decrease, Global DNA methylation	0	Molecular	Apr 30, 2020	Apr 30, 2020	4 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
1772	Decrease, Triglyceride Short Name Decrease, TAG	0	Cellular	Apr 30, 2020	May 27, 2024	329: Excessive reactive oxygen species production leading to mortality (3)
1771	Decrease, Adenosine triphosphate pool Short Name Decrease, ATP pool	1	Cellular	Apr 30, 2020	Jun 14, 2021	19 AOPs 328: Excessive reactive oxygen species production leading to mortality (2) 329: Excessive reactive oxygen species production leading to mortality (3) 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2) 286: Mitochondrial complex III antagonism leading to growth inhibition (1) 287: Mitochondrial complex III antagonism leading to growth inhibition (2) 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity 331: Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 598: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell proliferation 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate 326: Reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation 332: Reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation 333: Reactive oxygen species leading to growth inhibition via protein oxidation and cell death
1770	Decrease, Mitochondrial membrane potential Short Name Decrease, MMP	0	Cellular	Apr 30, 2020	Apr 30, 2020	3 AOPs 328: Excessive reactive oxygen species production leading to mortality (2) 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
1769	Increase, Body fluid overload Short Name Increase, Body fluid overload	0	Tissue	Apr 30, 2020	Apr 30, 2020	327: Excessive reactive oxygen species production leading to mortality (1)
1768	Increase, Abnormal osmoregulation Short Name Increase, Abnormal osmoregulation	0	Tissue	Apr 30, 2020	Aug 6, 2024	327: Excessive reactive oxygen species production leading to mortality (1)
1767	Increase, Protein oxidation Short Name Increase, Protein oxidation	1	Molecular	Apr 30, 2020	Jun 23, 2026	9 AOPs 327: Excessive reactive oxygen species production leading to mortality (1) 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 598: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell proliferation 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption 332: Reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation 333: Reactive oxygen species leading to growth inhibition via protein oxidation and cell death
1765	Increase, Formation of DNA photoproducts Short Name	0	Molecular	Apr 30, 2020	Apr 30, 2020	None
1763	Urothelial Tumor Short Name carcinogenicity	0	Organ	Apr 21, 2020	Apr 21, 2020	335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
1762	Urothelial cell injury/death Short Name cell injury	0	Cellular	Apr 21, 2020	Apr 21, 2020	335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
1761	Inhibition, Fin regeneration Short Name Inhibition, Fin regeneration	1	Tissue	Apr 21, 2020	Jul 10, 2020	334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
1758	Impaired, Spermatogenesis Short Name Impaired, Spermatogenesis	1	Organ	Apr 16, 2020	Apr 10, 2024	5 AOPs 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory 521: Essential element imbalance leads to reproductive failure via oxidative stress 526: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis 595: Emerging OPFRS reproductive outcome pathway
1757	Decrease, Sperm count Short Name Decrease, Sperm count	0	Individual	Apr 6, 2020	Jul 2, 2026	3 AOPs 322: Alkylation of DNA leading to decreased sperm count 400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility 616: organic UV filter and its Photoproducts reproductive toxicity pathways
1756	Decreased, plasma 11-ketotestosterone level Short Name Decreased, 11KT	1	Tissue	Mar 23, 2020	May 24, 2022	3 AOPs 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
1755	beta-catenin activation Short Name beta-catenin activation	1	Cellular	Mar 23, 2020	Nov 25, 2022	298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer
1754	Increase, porcupine-induced Wnt secretion and Wnt signaling activation Short Name	1	Cellular	Mar 23, 2020	Jun 4, 2025	298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer
1753	Chronic reactive oxygen species Short Name Chronic ROS	1	Molecular	Mar 23, 2020	Jun 12, 2025	None
1752	Increased Angiotensin II Short Name Increased AngII	0	Cellular	Mar 17, 2020	Apr 4, 2021	4 AOPs 319: Binding to ACE2 leading to lung fibrosis 384: Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease 385: Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation 381: Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
1751	Decreased mortality Short Name Decreased mortality	0	Individual	Mar 17, 2020	Mar 17, 2020	None
1750	Increased inflammatory immune responses Short Name Increased inflammatory immune responses	0	Tissue	Mar 10, 2020	Jan 21, 2021	2 AOPs 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
1748	Increase, the risk of acute respiratory failure Short Name	0	Organ	Mar 10, 2020	Mar 10, 2020	2 AOPs 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1746	Induction lung fibrosis Short Name Induction lung fibrosis	0	Organ	Mar 10, 2020	Mar 10, 2020	None
1745	Increase,collagen synthesis Short Name Increase,collagen synthesis	0	Cellular	Mar 10, 2020	Mar 10, 2020	None