Key Event Relationships (KERs)

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Showing 726 to 750 of 3081 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
135 328: Decrease, Fecundity 361: Decline, Population Nov 29, 2016 Dec 3, 2016 None
1886 328: Decrease, Fecundity 360: Decrease, Population growth rate Apr 22, 2019 Apr 22, 2019
2621 328: Decrease, Fecundity 1863: Decrease, Reproduction Mar 28, 2022 Mar 28, 2022
2115 1781: Decrease, Fecundity (F3) 360: Decrease, Population growth rate Apr 30, 2020 Apr 30, 2020
1472 330: Decrease, Fertility 360: Decrease, Population growth rate Apr 15, 2017 Apr 15, 2017 None
1345 1265: Decrease, Ftz-f1 expression 988: Decrease, Circulating ETH Feb 9, 2017 Feb 9, 2017
2722 2040: Decrease, GLI1/2 target gene expression 1821: Decrease, Cell proliferation Jul 28, 2022 Nov 17, 2022 None
2723 2040: Decrease, GLI1/2 target gene expression 1365: Increase, Apoptosis Jul 28, 2022 Jul 28, 2022 None
2731 2040: Decrease, GLI1/2 target gene expression 2043: Decrease, SHH second messenger production Aug 23, 2022 Apr 3, 2025
2805 2040: Decrease, GLI1/2 target gene expression 2041: Decrease, facial prominence outgrowth Nov 17, 2022 Nov 17, 2022 None
2882 2040: Decrease, GLI1/2 target gene expression 1262: Apoptosis Apr 6, 2023 Apr 4, 2025
2721 2028: Decrease, GLI1/2 translocation 2040: Decrease, GLI1/2 target gene expression Jul 28, 2022 Apr 2, 2025
2102 1773: Decrease, Global DNA methylation 1774: Increase, Casp transcription Apr 30, 2020 Apr 30, 2020
2110 1773: Decrease, Global DNA methylation 1778: Decrease, Heritable DNA methylation (F3) Apr 30, 2020 Apr 30, 2020
2795 2071: Decrease, Glucose pool 1821: Decrease, Cell proliferation Nov 1, 2022 Nov 1, 2022
2530 1951: Decrease, Glucose uptake 1952: Abnormal, Glucose homeostasis Nov 18, 2021 Nov 18, 2021
2529 1949: Decrease, GLUT4 1951: Decrease, Glucose uptake Nov 18, 2021 Nov 18, 2021
1668 1476: Decrease, Glycolysis 1477: OXPHOS, decreased Oct 10, 2017 Oct 10, 2017
1738 1476: Decrease, Glycolysis 40: Mitochondrial ATP production, decreased May 24, 2018 May 24, 2018 None
2169 1521: Decrease, Growth 360: Decrease, Population growth rate Oct 8, 2020 Oct 8, 2020 None
2804 1521: Decrease, Growth 1141: Decreased, Reproductive Success Nov 16, 2022 Nov 16, 2022
2111 1778: Decrease, Heritable DNA methylation (F3) 1779: Increase, Casp transcription (F3) Apr 30, 2020 Apr 30, 2020
649 633: Decrease, histaminergic neuron excitation 634: N/A, sedation Nov 29, 2016 Dec 3, 2016
1643 633: Decrease, histaminergic neuron excitation 341: Impairment, Learning and memory Aug 11, 2017 Aug 11, 2017
791 788: Decrease, Incorporation of active iodide into iodotyrosines 771: Decrease, Serum thyroid hormone (T4/T3) Nov 29, 2016 Dec 3, 2016 None