Key Event Relationships (KERs)

API

Fulltext search has been disabled for Key Event Relationships (KERs) at this time. If you need this feature, send an email to aopwiki@googlegroups.com

Queries Key Event Relationship (KER) titles
Filter by Upstream Key Event title
Filter by Downstream Key Event title
Filter by AOP title
Clear All Filters

Showing 1351 to 1375 of 3119 KERs

Clear Table Filters
ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2798 1632: Increase in RONS 2073: methemocyanin formation (decrease overall oxygen binding capacity) Nov 16, 2022 Nov 16, 2022
3268 1632: Increase in RONS 1392: Increase, Oxidative Stress Jul 4, 2024 Jul 4, 2024
3565 1632: Increase in RONS 1767: Increase, Protein oxidation Aug 13, 2025 Aug 13, 2025 None
3566 1632: Increase in RONS 1445: Increase, LPO Aug 13, 2025 Aug 13, 2025 None
3567 1632: Increase in RONS 1634: Increase, Oxidative DNA damage Aug 13, 2025 Aug 13, 2025 None
1795 1553: Increase mutations 1555: Increase cell proliferation Dec 19, 2018 Dec 19, 2018 None
1800 1553: Increase mutations 1556: Increase, lung cancer Dec 19, 2018 Dec 19, 2018 None
1900 1553: Increase mutations 1182: Increase, Cell Proliferation (Epithelial Cells) May 7, 2019 May 7, 2019 None
3237 1553: Increase mutations 885: Increase, Cancer May 28, 2024 May 28, 2024 None
2023 1713: Increase of autoantibody production 1714: Exacerbation of SLE Dec 29, 2019 Aug 14, 2020
2022 1712: Increase of Th2 cells producing IL-4 1713: Increase of autoantibody production Dec 29, 2019 Aug 14, 2020
2799 2073: methemocyanin formation (decrease overall oxygen binding capacity) 2074: Decrease overall oxygen binding capacity (methemocyanin formation) Nov 16, 2022 Nov 16, 2022
2800 2073: methemocyanin formation (decrease overall oxygen binding capacity) 2075: Hemocyanin Bohr effect decrease Nov 16, 2022 Nov 16, 2022
2067 1743: Increase plasma Ang II 1745: Increase,collagen synthesis Mar 17, 2020 Mar 17, 2020 None
2138 1743: Increase plasma Ang II 68: Increase, Collagen accumulation May 15, 2020 May 15, 2020 None
2435 1743: Increase plasma Ang II 1852: Increased Ang II type 1 receptor (AT1R) Jul 13, 2021 Jul 13, 2021
398 416: Increase proliferation, Leydig cell 415: Hyperplasia, Leydig cell Nov 29, 2016 Dec 3, 2016
2748 2054: Increase, impairment of cuticle sclerotization 990: Increase, Incomplete ecdysis Aug 28, 2022 Aug 28, 2022
2749 2055: Increase, pigmentation 990: Increase, Incomplete ecdysis Aug 28, 2022 Aug 28, 2022
3741 2410: Increase, 11β-HSD1 activity 2412: Increase, Hepatic intracellular active GC Feb 24, 2026 Feb 24, 2026
2836 2098: Abnormal Neural Remodeling 341: Impairment, Learning and memory Jan 25, 2023 Jul 26, 2024
2091 1768: Increase, Abnormal osmoregulation 1769: Increase, Body fluid overload Apr 30, 2020 Apr 30, 2020
2181 1768: Increase, Abnormal osmoregulation 1809: Increase, Tissue/organ damage Nov 2, 2020 Nov 2, 2020 None
3290 1768: Increase, Abnormal osmoregulation 2238: Increased, Blood viscosity Jul 8, 2024 Dec 3, 2024 None
3722 2408: Increase, Adipose lipolysis 115: Increase, FA influx Feb 10, 2026 Feb 10, 2026 None