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Showing 1876 to 1900 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3670	2380: Increase, dopamine transporter gene	746: Increase, Dopaminergic activity	Oct 20, 2025	Oct 20, 2025	1 AOP 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
1354	1271: Activation of TGF-β signaling	1272: Increase, Myofibroblast expansion	Feb 15, 2017	Feb 15, 2017	None
1355	1271: Activation of TGF-β signaling	1273: Expression of Collagen	Feb 15, 2017	Feb 15, 2017	None
1721	1271: Activation of TGF-β signaling	149: Increase, Inflammation	Mar 18, 2018	Mar 18, 2018	1 AOP 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
1723	1271: Activation of TGF-β signaling	1457: EMT	Mar 18, 2018	Mar 18, 2018	None
3728	1271: Activation of TGF-β signaling	265: Increase, HSC activation	Feb 10, 2026	Feb 10, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
3732	1271: Activation of TGF-β signaling	1606: Activation, Stellate cell	Feb 11, 2026	Feb 11, 2026	None
1663	1471: Increase, Uncoupling of photophosphorylation	1472: Decrease, ATP production	Oct 10, 2017	Oct 10, 2017	1 AOP 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
795	793: Increase, Urinary bladder calculi	794: Increase, Cytotoxicity (urothelial cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 121: Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)
3018	2161: Increase, Vascular disrupting effects	2160: Angiogenesis disfunction	Aug 21, 2023	Aug 21, 2023	None
1444	1342: Increase, vascular smooth muscle contraction	1343: Increase, hypertension	Apr 14, 2017	Apr 14, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
2738	2046: Increase, Vitellogenin mRNA	2047: Delay, Ovarian maturation	Aug 28, 2022	Aug 28, 2022	1 AOP 465: Alcohol dehydrogenase leading to reproductive dysfunction
336	307: Increase, Vitellogenin synthesis in liver	220: Increase, Plasma vitellogenin concentrations	Nov 29, 2016	Jun 24, 2024	3 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver
2068	1745: Increase,collagen synthesis	1746: Induction lung fibrosis	Mar 17, 2020	Mar 17, 2020	None
2527	1888: increased atRA concentration	1889: premature meiosis, male germ cells	Nov 10, 2021	Nov 11, 2021	1 AOP 400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility
2509	1948: Upregulation of ACE2	1738: SARS-CoV-2 cell entry	Oct 28, 2021	Oct 28, 2021	None
1238	1172: Increased activation, Nuclear factor kappa B (NF-kB)	1170: Increase, Phenotypic enzyme activity	Nov 29, 2016	Dec 3, 2016	None
2309	1172: Increased activation, Nuclear factor kappa B (NF-kB)	1496: Increased proinflammatory mediators	Mar 30, 2021	Mar 30, 2021	3 AOPs 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 319: Binding to ACE2 leading to lung fibrosis
2431	1172: Increased activation, Nuclear factor kappa B (NF-kB)	87: Release, Cytokine	Jul 8, 2021	Jul 8, 2021	1 AOP 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
2432	1172: Increased activation, Nuclear factor kappa B (NF-kB)	1493: Increased pro-inflammatory mediators	Jul 8, 2021	Jul 8, 2021	1 AOP 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
2612	1172: Increased activation, Nuclear factor kappa B (NF-kB)	112: Antagonism, Estrogen receptor	Mar 22, 2022	Aug 27, 2023	1 AOP 443: DNA damage and mutations leading to Metastatic Breast Cancer
1080	1039: Increased activity, beta-2 adrenergic receptor	1040: relaxation, smooth muscle	Nov 29, 2016	Dec 3, 2016	1 AOP 164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
2898	2128: Increased adipocyte numbers	2125: Increased fat mass	May 4, 2023	May 4, 2023	1 AOP 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
2899	2127: Increased adipocyte size	2125: Increased fat mass	May 4, 2023	May 4, 2023	1 AOP 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
1612	1449: increased adipogenesis	1447: obesity	Jul 24, 2017	Jul 24, 2017	1 AOP 72: Epigenetic modification of PPARG leading to adipogenesis

Key Event Relationships (KERs)

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