Prototypical Stressors

Showing 426 to 450 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

119	Immepip		None
678	Impregnation products		None
272	Increase cortisone levels (induced by stress)		3 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation
872	Indeno(1,2,3-cd)pyrene	Indeno(1,2,3-cd)pyrene, CAS-RN: 193-39-5, DTXSID8024153	2 AOPs 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
158	Indole	Indole, CAS-RN: 120-72-9, DTXSID0020737	None
27	Indomethacin	1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-Indole-3-acetic acid, CAS-RN: 53-86-1, DTXSID9020740	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
699	Influenza Virus		506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
613	inguratimod		None
246	Inokosterone	Inokosterone, CAS-RN: 15130-85-5, DTXSID40164756	4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1
377	Insoluble nano-sized particles		237: Substance interaction with lung resident cell membrane components leading to atherosclerosis via acute phase response
508	Interleukin-6	Interleukin-6, CAS-RN: 308067-66-5, DTXSID6041050	309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
269	Iodine deficiency		None
451	Ionizing Radiation		25 AOPs 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer 298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 388: Deposition of ionising energy leading to population decline via programmed cell death 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 396: Deposition of ionizing energy leads to population decline via impaired meiosis 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation 470: Deposition of energy leads to abnormal vascular remodeling 483: Deposition of Energy Leading to Learning and Memory Impairment 482: Deposition of energy leading to occurrence of bone loss 478: Deposition of energy leading to occurrence of cataracts 550: Increased LMNA gene mutation leading to heart failure 324: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption 325: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death 326: Reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation 331: Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 332: Reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation 333: Reactive oxygen species leading to growth inhibition via protein oxidation and cell death
212	iopanoic acid	Iopanoic acid, CAS-RN: 96-83-3, DTXSID6023159	155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation
617	IRAK4 inhibitors		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
232	Iron compounds		None
750	Iron nanoparticles		392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation
662	Irradiation		None
825	Isobutylmethylxanthine	Isobutylmethylxanthine, CAS-RN: 28822-58-4, DTXSID0040549	561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
258	Isoflavones		152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
352	Isoflurane	Isoflurane, CAS-RN: 26675-46-7, DTXSID3020752	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
358	Isoniazid	Isoniazid, CAS-RN: 54-85-3, DTXSID8020755	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
28	Isopropyl methanesulfonate	Isopropyl methanesulfonate, CAS-RN: 926-06-7, DTXSID8031497	None
795	Isoproterenol		2 AOPs 554: β-adrenergic receptor agonists leading to arrhythmias. 558: Phosphodiesterase inhibition leading to heart failure
690	Itraconazole	Itraconazole, CAS-RN: 84625-61-6, DTXSID3023180	None