Prototypical Stressors

Showing 426 to 450 of 853 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

232	Iron compounds		None
750	Iron nanoparticles		392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation
662	Irradiation		None
825	Isobutylmethylxanthine	Isobutylmethylxanthine, CAS-RN: 28822-58-4, DTXSID0040549	561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
258	Isoflavones		152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
352	Isoflurane	Isoflurane, CAS-RN: 26675-46-7, DTXSID3020752	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
358	Isoniazid	Isoniazid, CAS-RN: 54-85-3, DTXSID8020755	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
28	Isopropyl methanesulfonate	Isopropyl methanesulfonate, CAS-RN: 926-06-7, DTXSID8031497	None
795	Isoproterenol		2 AOPs 554: β-adrenergic receptor agonists leading to arrhythmias. 558: Phosphodiesterase inhibition leading to heart failure
690	Itraconazole	Itraconazole, CAS-RN: 84625-61-6, DTXSID3023180	None
811	Ivabradine		2 AOPs 560: Inhibition of Funny current (If) leading to Arrhythmias 562: HCN Channel Inhibition leading to Arrhythmias
531	Kaempferol	Kaempferol, CAS-RN: 520-18-3, DTXSID7020768	154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
29	Kainic acid	Kainic acid, CAS-RN: 487-79-6, DTXSID7040526	None
397	KCN	Potassium cyanide, CAS-RN: 151-50-8, DTXSID0024268	None
475	Kenpaullone		None
282	Ketoconazole	Ketoconazole, CAS-RN: 65277-42-1, DTXSID7029879	4 AOPs 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
181	Ketoprofen	Ketoprofen, CAS-RN: 22071-15-4, DTXSID6020771	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
186	Ketorolac Tromethamine	Ketorolac tromethamine, CAS-RN: 74103-07-4, DTXSID0045597	None
217	kinoprene	Kinoprene, CAS-RN: 42588-37-4, DTXSID3032624	201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
109	Lambda-Cyhalothrin	λ-Cyhalothrin, CAS-RN: 91465-08-6, DTXSID7032559	None
59	Lead	Lead, CAS-RN: 7439-92-1, DTXSID2024161	8 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure 556: Decreased Na/K ATPase activity leading to heart failure 558: Phosphodiesterase inhibition leading to heart failure 560: Inhibition of Funny current (If) leading to Arrhythmias
30	Lead(II)		None
31	Lead(II) acetate trihydrate	Lead(II) acetate trihydrate, CAS-RN: 6080-56-4, DTXSID3031521	None
760	Lei Gong Teng (Common Threewingnut Root)		486: Binding to the extracellular protein laminin leading to decreased cognitive function
32	Letrozole	Letrozole, CAS-RN: 112809-51-5, DTXSID4023202 Fadrozole, CAS-RN: 102676-47-1, DTXSID5034141	2 AOPs 153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation