AOPs

OECD View API
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Showing 1 to 25 of 30 Fulltext Results
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ID Title Point of Contact License MIE AO OECD Status OECD Project
40 Covalent Protein binding leading to Skin Sensitisation Undefined BY-SA 396: Covalent Binding, Protein 827: sensitisation, skin WPHA/WNT Endorsed 1.1
149 Peptide Oxidation Leading to Hypertension Frazer Lowe BY-SA 209: Peptide Oxidation 952: Hypertension Under Development 1.50
195 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase Kellie Fay BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 1164: Increased, Population
196 Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation Jeanelle Martinez BY-SA 1215: TRPA1 activation, TRPA1 Receptor
213 Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) Lyle Burgoon Open for adoption 1490: Inhibition, Fatty Acid Beta Oxidation 1489: Increase, Steatohepatitis
258 Renal protein alkylation leading to kidney toxicity Angela Mally BY-SA 244: Alkylation, Protein 814: Occurrence, Kidney toxicity Under Development 1.43
282 Adverse outcome pathway on photochemical toxicity initiated by light exposure Satomi Onoue BY-SA 1115: Increase, Reactive oxygen species 1599: Inflamatory events in light-exposed tissues Under Review 1.49
293 Increased DNA damage leading to increased risk of breast cancer Jessica Helm BY-SA 1194: Increase, DNA damage Under Development 1.80
294 Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer Jessica Helm BY-SA 1632: Increase in reactive oxygen and nitrogen species (RONS) Under Development 1.80
296 Oxidative DNA damage leading to chromosomal aberrations and mutations Carole Yauk BY-SA 1634: Increase, Oxidative DNA damage WPHA/WNT Endorsed 1.76
298 Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer Shihori Tanabe BY-SA 1115: Increase, Reactive oxygen species 1651: Treatment-resistant gastric cancer Under Review 1.58
324 Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and cell death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
362 Immune mediated hepatitis Jung-Hwa Oh BY-SA 1814: benzoquinone imine and acylglucuronide metabolites 1820: Immune mediated hepatitis
386 Deposition of ionizing energy leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
387 Deposition of ionising energy leading to population decline via mitochondrial dysfunction Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
396 Deposition of ionizing energy leads to population decline via impaired meiosis Erica Maremonti All rights reserved 1550: Deposition of Ionizing Energy
413 Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure Carmel Mothersill BY-SA 926: Oxidation, Glutathione (To be considered with MIE) 351: Increased Mortality
457 Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine Simon Thomas Open for adoption 2118: Succinate dehydrogenase, inhibited 2119: Increase, Insulin resistance
462 Activation of reactive oxygen species leading the atherosclerosis Hiromi Ohara BY-SA 1115: Increase, Reactive oxygen species None
470 Deposition of energy leads to abnormal vascular remodeling Vinita Chauhan BY-SA 1686: Deposition of Energy 2069: Occurrence, Abnormal Vascular Remodeling WPHA/WNT Endorsed 1.89
478 Deposition of energy leading to occurrence of cataracts Vinita Chauhan BY-SA 1686: Deposition of Energy 2083: Occurrence of Cataracts WPHA/WNT Endorsed 1.89
483 Deposition of Energy Leading to Learning and Memory Impairment Vinita Chauhan BY-SA 1686: Deposition of Energy 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.89
505 Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway John Frisch BY-SA 1115: Increase, Reactive oxygen species 885: Increase, Cancer
511 The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects Yanhong Wei All rights reserved 1115: Increase, Reactive oxygen species 2161: Increase, Vascular disrupting effects
513 Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway John Frisch BY-SA 1115: Increase, Reactive oxygen species 885: Increase, Cancer