Key Event Relationships (KERs)

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Showing 3126 to 3150 of 3164 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1284 1215: TRPA1 activation, TRPA1 Receptor 1235: Non-neuronal production of IL-8/CXCL1, Epithelial irritation Nov 29, 2016 Dec 3, 2016 None
1576 1215: TRPA1 activation, TRPA1 Receptor 1236: Generation of novel epitopes , Antigen presentation Jun 23, 2017 Jun 23, 2017 None
1281 1230: TRPV1 activation, TRPV1 1218: Opening of calcium channel, Calcium influx Nov 29, 2016 Nov 29, 2016 None
2028 1720: Inhibition, trypsin 1721: Increased monitor peptide Jan 8, 2020 Jan 8, 2020
1196 1150: Uncarboxylated osteocalcin not incorporated into bone matrix, decreasing bone strength, Imp 1151: Osteoporosis and vascular calcification, Bone deterioration Nov 29, 2016 Dec 3, 2016 None
1168 1122: Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failur 1130: Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage) Nov 29, 2016 Dec 3, 2016
1732 1512: Unfolded Protein Response 1513: General Apoptosis Apr 4, 2018 Apr 5, 2018
1866 1512: Unfolded Protein Response 1262: Apoptosis Mar 6, 2019 Mar 6, 2019
2712 1512: Unfolded Protein Response 1825: Increase, Cell death Jul 25, 2022 Jul 25, 2022 None
3041 1512: Unfolded Protein Response 2188: Caspase activation Sep 14, 2023 Sep 14, 2023
1161 1114: Unknown, MIE 1115: Increase, ROS Nov 29, 2016 Dec 3, 2016
2035 1114: Unknown, MIE 1113: Unknown, Jan 26, 2020 Jan 26, 2020 None
2036 1114: Unknown, MIE 294: N/A, Unknown Jan 26, 2020 Jan 26, 2020 None
517 470: Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1) 458: Increased, De Novo FA synthesis Nov 29, 2016 Dec 3, 2016
66 54: Up Regulation, CD36 115: Increase, FA influx Nov 29, 2016 Mar 27, 2024
501 54: Up Regulation, CD36 465: Increased, FA Influx Nov 29, 2016 Dec 3, 2016
2262 54: Up Regulation, CD36 460: Increased, Fatty acid uptake Jan 15, 2021 Jan 15, 2021 None
96 80: Up Regulation, CYP1A1 209: Peptide Oxidation Nov 29, 2016 Dec 3, 2016 None
3817 80: Up Regulation, CYP1A1 1392: Increase, Oxidative Stress Jul 9, 2026 Jul 9, 2026
104 84: Up Regulation, CYP1B1 3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells Nov 29, 2016 Dec 3, 2016 None
492 463: Up Regulation, FAS 458: Increased, De Novo FA synthesis Nov 29, 2016 Dec 3, 2016
507 466: Up Regulation, LDLR (low density lipoprotein receptor) 467: Increased, LDL uptake Nov 29, 2016 Dec 3, 2016
493 462: Up Regulation, SCD-1 454: Increased, Triglyceride formation Nov 29, 2016 Dec 3, 2016
1657 462: Up Regulation, SCD-1 291: Accumulation, Triglyceride Aug 31, 2017 Aug 31, 2017
1371 1284: Up Regulation, SREBF2 1285: Up Regulation, Unsaturated fatty acid Feb 15, 2017 Feb 15, 2017