AOP-Wiki

API

All KERs

Showing 1001 to 1025 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

334	304: Decreased, VegfR2	305: Inhibition, VegfR2	Nov 29, 2016	Dec 3, 2016	None
2938	2147: Decreased, Viable Offspring	360: Decrease, Population growth rate	Jun 2, 2023	Sep 29, 2023	1 AOP 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone
1383	1295: Defect of Embryogenesis	1277: Reproductive failure	Feb 15, 2017	Feb 15, 2017	1 AOP 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
907	890: Degeneration of dopaminergic neurons of the nigrostriatal pathway	188: Neuroinflammation	Nov 29, 2016	Oct 2, 2017	1 AOP 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
910	890: Degeneration of dopaminergic neurons of the nigrostriatal pathway	896: Parkinsonian motor deficits	Nov 29, 2016	Oct 3, 2025	5 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 587: Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits 588: Inhibition of the mitochondrial complex II of nigro-striatal neurons leads to parkinsonian motor deficits 589: Inhibition of the mitochondrial complex IV of nigro-striatal neurons leads to parkinsonian motor deficits 593: Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons
3077	890: Degeneration of dopaminergic neurons of the nigrostriatal pathway	637: impaired, Learning and memory	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
447	428: Delay, Developmental GABA shift	385: Synaptogenesis, Decreased	Nov 29, 2016	Dec 3, 2016	None
2739	2047: Delay, Ovarian maturation	2048: Increase, Body volume of female adults	Aug 28, 2022	Aug 28, 2022	1 AOP 465: Alcohol dehydrogenase leading to reproductive dysfunction
2740	2047: Delay, Ovarian maturation	2049: Increase, sex ratio (F/M)	Aug 28, 2022	Aug 28, 2022	1 AOP 465: Alcohol dehydrogenase leading to reproductive dysfunction
1182	1140: Delayed, Sexual maturity	1141: Decreased, Reproductive Success	Nov 29, 2016	Dec 3, 2016	None
3355	2266: Demyelination, increased	2267: Delayed neuropathy, increased	Oct 1, 2024	Oct 1, 2024	2 AOPs 543: Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration 544: Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation
3664	2266: Demyelination, increased	2378: Impaired axonal insulation	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
1181	1143: Depletion, energy reserves	1140: Delayed, Sexual maturity	Nov 29, 2016	Dec 3, 2016	None
1185	1143: Depletion, energy reserves	623: Increase, predation	Nov 29, 2016	Dec 3, 2016	1 AOP 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
2878	130: Depletion, GSH	1115: Increase, ROS	Apr 5, 2023	Sep 14, 2023	1 AOP 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress
3133	1482: Depletion, mtDNA	177: Increase, Mitochondrial dysfunction	Feb 28, 2024	Feb 28, 2024	1 AOP 256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
1977	1686: Energy Deposition	1635: Increase, DNA strand breaks	Aug 26, 2019	Jul 29, 2024	6 AOPs 272: Deposition of energy leading to lung cancer 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 478: Deposition of energy leading to occurrence of cataracts 470: Deposition of energy leads to abnormal vascular remodeling 483: Deposition of Energy Leading to Learning and Memory Impairment
1981	1686: Energy Deposition	185: Increase, Mutations	Aug 29, 2019	Dec 17, 2024	2 AOPs 272: Deposition of energy leading to lung cancer 478: Deposition of energy leading to occurrence of cataracts
1982	1686: Energy Deposition	1636: Increase, Chromosomal aberrations	Aug 29, 2019	Dec 17, 2024	2 AOPs 272: Deposition of energy leading to lung cancer 478: Deposition of energy leading to occurrence of cataracts
1983	1686: Energy Deposition	1556: Increase, lung cancer	Aug 29, 2019	Jul 5, 2023	1 AOP 272: Deposition of energy leading to lung cancer
2548	1686: Energy Deposition	1115: Increase, ROS	Jan 21, 2022	Jan 21, 2022	4 AOPs 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
2552	1686: Energy Deposition	1194: Increase, DNA Damage	Jan 21, 2022	Jan 21, 2022	4 AOPs 388: Deposition of ionising energy leading to population decline via programmed cell death 435: Deposition of ionising energy leads to population decline via pollen abnormal 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
2604	1686: Energy Deposition	1978: Microcephaly	Mar 17, 2022	Mar 17, 2022	1 AOP 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
2616	1686: Energy Deposition	1632: Increase in RONS	Mar 28, 2022	Mar 28, 2022	2 AOPs 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
2769	1686: Energy Deposition	1392: Increase, Oxidative Stress	Sep 28, 2022	Aug 26, 2024	4 AOPs 470: Deposition of energy leads to abnormal vascular remodeling 483: Deposition of Energy Leading to Learning and Memory Impairment 482: Deposition of energy leading to occurrence of bone loss 478: Deposition of energy leading to occurrence of cataracts

Key Event Relationships (KERs)

All KERs