AOPs

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Showing 326 to 350 of 588 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
311 Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis You Song BY-SA 1686: Deposition of Energy
310 Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR Jon Doering BY-SA 18: Activation, AhR
309 Luteinizing hormone receptor antagonism leading to reproductive dysfunction Young Jun Kim BY-SA 1691: Antagonism,LH receptor 679: Decline, Population trajectory
307 Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen BY-SA None 1688: anogenital distance (AGD), decreased Under Review 1.90
306 Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen BY-SA 26: Antagonism, Androgen receptor 1688: anogenital distance (AGD), decreased Under Review 1.90
305 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen BY-SA 1617: Inhibition, 5α-reductase 1688: anogenital distance (AGD), decreased Under Review 1.90
304 TBX1 inhibition leading to congenital cardiac conotruncal anomalies Jinsoo Lee BY-SA 1680: Inhibition, TBX1 1685: Anomalies, Congenital cardiac conotruncal
303 Frustrated phagocytosis-induced lung cancer Carole Seidel BY-SA 1668: Frustrated phagocytosis 1670: Lung cancer Under Development 1.86
302 Lung surfactant function inhibition leading to decreased lung function Jorid Birkelund Sørli BY-SA 1672: Inhibition of lung surfactant function 1250: Decrease, Lung function Under Development 1.87
301 Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis Young Jun Kim BY-SA 1657: Inhibition of cystathionine beta-synthase 1667: Impaired,anterior-posterior axis development
300 Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton BY-SA 1656: Antagonism, Thyroid Receptor 402: Cognitive function, decreased Under Development 1.84
299 Deposition of energy leading to population decline via DNA oxidation and follicular atresia You Song BY-SA 1686: Deposition of Energy
298 Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer Shihori Tanabe BY-SA 1115: Increase, Reactive oxygen species 1651: Treatment-resistant gastric cancer Under Review 1.58
297 Inhibition of retinaldehyde dehydrogenase leads to population decline Young Jun Kim BY-SA 1637: Retinaldehyde dehydrogenase inhibition 360: Decrease, Population growth rate Under Development 1.77
296 Oxidative DNA damage leading to chromosomal aberrations and mutations Carole Yauk BY-SA 1634: Increase, Oxidative DNA damage WPHA/WNT Endorsed 1.76
295 Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk Andrea Hindman BY-SA None None Under Development 1.79
294 Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer Jessica Helm BY-SA 1632: Increase in reactive oxygen and nitrogen species (RONS) Under Development 1.80
293 Increased DNA damage leading to increased risk of breast cancer Jessica Helm BY-SA 1194: Increase, DNA damage Under Development 1.80
292 Inhibition of tyrosinase leads to decreased population in fish Young Jun Kim BY-SA 1627: Inhibition of tyrosinase 360: Decrease, Population growth rate Under Development 1.78
291 Mitochondrial ATP synthase antagonism leading to growth inhibition (2) You Song BY-SA 1785: Increase, Mitochondrial ATP synthase antagonism 1521: Decrease, Growth
290 Mitochondrial ATP synthase antagonism leading to growth inhibition (1) You Song BY-SA 1785: Increase, Mitochondrial ATP synthase antagonism 1521: Decrease, Growth
289 Inhibition of 5α-reductase leading to impaired fecundity in female fish Young Jun Kim BY-SA 1617: Inhibition, 5α-reductase 360: Decrease, Population growth rate Under Development 1.81
288 Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) Bérénice COLLET BY-SA 1609: Inhibition, Cytochrome P450 enzyme (CYP17A1) activity 1616: Malformation, cryptorchidism - maldescended testis
287 Mitochondrial complex III antagonism leading to growth inhibition (2) You Song BY-SA 1542: Inhibition, Mitochondrial complex III 1521: Decrease, Growth
286 Mitochondrial complex III antagonism leading to growth inhibition (1) You Song BY-SA 1542: Inhibition, Mitochondrial complex III 1521: Decrease, Growth