AOPs

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Showing 576 to 588 of 588 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
17 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory Marie-Gabrielle Zurich BY-SA 1487: Binding, Thiol/seleno-proteins involved in protection against oxidative stress 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.13
16 Acetylcholinesterase inhibition leading to acute mortality Dan Villeneuve BY-SA 12: Acetylcholinesterase (AchE) Inhibition Under Development 1.3
15 Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Carole Yauk BY-SA 97: Alkylation, DNA 336: Increase, Heritable mutations in offspring WPHA/WNT Endorsed 1.11
14 Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Carlie LaLone BY-SA 122: Increase, Glucocorticoid receptor activation 323: Increased, Disease susceptibility
13 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Anna Price BY-SA 201: Binding of antagonist, NMDA receptors 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.22
12 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging Florianne Tschudi-Monnet BY-SA 201: Binding of antagonist, NMDA receptors WPHA/WNT Endorsed 1.13
11 Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol Jun Kanno BY-SA 245: Activation, PXR/SXR None Under Development 2.5
10 Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain Ping Gong BY-SA 667: Binding at picrotoxin site, iGABAR chloride channel 613: Occurrence, Epileptic seizure WPHA/WNT Endorsed 1.15
8 Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Katie Paul Friedman Open for adoption 239: Activation, Pregnane-X receptor, NR1I2 319: Loss, Cochlear function Under Development 1.9
7 Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female Elise Grignard BY-SA 408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1) Under Review 1.21
6 Antagonist binding to PPARĪ± leading to body-weight loss Kurt A. Gust BY-SA 998: Binding of antagonist, PPAR alpha 864: Decreased, Body Weight WPHA/WNT Endorsed 2.3
4 Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 Knut Erik Tollefsen BY-SA 103: Increase, Ecdysone receptor hyperactivation
3 Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Andrea Terron BY-SA 888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) 896: Parkinsonian motor deficits WPHA/WNT Endorsed 1.33