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All Key Events

Showing 1051 to 1075 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1504	p21 (CDKN1A) expression, increase Short Name p21 (CDKN1A) expression, increase	1	Cellular	Jan 21, 2018	Nov 26, 2018	None
1505	Cell cycle, disrupted Short Name Cell cycle, disrupted	1	Cellular	Jan 21, 2018	Jun 30, 2021	7 AOPs 212: Histone deacetylase inhibition leading to testicular atrophy 393: AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation 396: Deposition of ionizing energy leads to population decline via impaired meiosis 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
1506	Testicular atrophy Short Name Testicular atrophy	1	Organ	Jan 21, 2018	Jul 1, 2021	212: Histone deacetylase inhibition leading to testicular atrophy
1507	Activation of PPARγ Short Name Activation of PPARγ	0	Molecular	Mar 18, 2018	Mar 18, 2018	None
1508	CYP2E1 Activation Short Name CYP2E1 Activation	0	Molecular	Mar 26, 2018	Apr 9, 2018	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
1509	Protein Adduct Formation Short Name Protein Adduct Formation	0	Molecular	Mar 26, 2018	Mar 26, 2018	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
1511	Lipid Peroxidation Short Name Lipid Peroxidation	0	Molecular	Apr 4, 2018	Apr 4, 2018	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
1512	Unfolded Protein Response Short Name Unfolded Protein Response	0	Molecular	Apr 4, 2018	Sep 14, 2023	3 AOPs 260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration 285: Inhibition of N-linked glycosylation leads to liver injury 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
1513	General Apoptosis Short Name General Apoptosis	1	Cellular	Apr 4, 2018	Oct 18, 2023	3 AOPs 260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration 505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway 513: Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
1514	Neurodegeneration Short Name Neurodegeneration	0	Organ	Apr 4, 2018	Apr 4, 2018	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
1515	Spermatocyte depletion Short Name Spermatocyte depletion	1	Tissue	May 2, 2018	Jul 28, 2021	212: Histone deacetylase inhibition leading to testicular atrophy
1516	Increase, D1 protein antagonism Short Name Increase, D1 protein antagonism	0	Molecular	May 24, 2018	Oct 7, 2020	None
1517	Decrease, Photosystem II activity Short Name Decrease, PSII activity	0	Molecular	May 24, 2018	Oct 7, 2020	None
1519	Glycolysis Short Name Glycolysis	0	Cellular	May 24, 2018	May 24, 2018	None
1521	Decrease, Growth Short Name Decrease, Growth	1	Individual	May 24, 2018	Jul 6, 2022	25 AOPs 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2) 286: Mitochondrial complex III antagonism leading to growth inhibition (1) 287: Mitochondrial complex III antagonism leading to growth inhibition (2) 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants 265: Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity 267: Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion 268: Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin 326: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell proliferation 331: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 332: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell growth 333: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell proliferation 325: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell growth 324: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and cell death 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 598: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell proliferation 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation
1522	Inhibition, Chitin synthase 1 Short Name Inhibition, CHS-1	1	Molecular	May 24, 2018	Feb 24, 2021	2 AOPs 360: Chitin synthase 1 inhibition leading to mortality 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
1523	Decrease, Cuticular chitin content Short Name Decrease, Cuticular chitin content	1	Tissue	May 24, 2018	Feb 17, 2021	3 AOPs 360: Chitin synthase 1 inhibition leading to mortality 361: Sulfonylureareceptor binding leading to mortality 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
1524	Increase, Premature molting Short Name Increase, Premature molting	1	Individual	May 24, 2018	Feb 17, 2021	5 AOPs 358: Chitinase inhibition leading to mortality 359: Chitobiase inhibition leading to mortality 360: Chitin synthase 1 inhibition leading to mortality 361: Sulfonylureareceptor binding leading to mortality 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
1525	Increase, Sulfonylurea receptor binding Short Name Increase, SUR binding	0	Molecular	May 24, 2018	May 24, 2018	361: Sulfonylureareceptor binding leading to mortality
1526	Increase, Opening of voltage-dependent calcium channel Short Name	0	Cellular	May 24, 2018	May 24, 2018	361: Sulfonylureareceptor binding leading to mortality
1527	Increase, Cell membrane depolarization Short Name Increase, Cell membrane depolarization	0	Cellular	May 24, 2018	May 24, 2018	3 AOPs 361: Sulfonylureareceptor binding leading to mortality 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity
1528	Fatty Acid Beta Oxidation, Decreased Short Name Fatty Acid Beta Oxidation, Decreased	1	Molecular	Jun 11, 2018	Apr 30, 2019	6: Antagonist binding to PPARα leading to body-weight loss
1529	Blockade, L-Type Calcium Channels Short Name Blockade, L-Type Calcium Channels	0	Molecular	Jun 19, 2018	Nov 1, 2018	2 AOPs 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)
1530	Decrease, Calcium currents Short Name Decrease, Calcium currents	0	Cellular	Jun 19, 2018	Jun 19, 2018	261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
1531	Decrease, Calcium binding to Troponin C Short Name Decrease, Calcium binding to Troponin C	0	Cellular	Jun 19, 2018	Jun 19, 2018	261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility