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Showing 651 to 675 of 3164 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2752	2058: Decrease, 20-hydroxyecdysone	2059: Decrease, knickkopf gene	Aug 28, 2022	Aug 28, 2022	1 AOP 467: Knickkopf leading to mortality
1010	993: Decrease, Abdominal muscle contraction	990: Increase, Incomplete ecdysis	Nov 29, 2016	Dec 3, 2016	3 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
2267	1834: Decrease, ACAD	860: Decreased, Mitochondrial Fatty Acid Beta Oxidation	Jan 15, 2021	Jan 15, 2021	1 AOP 318: Glucocorticoid Receptor activation leading to hepatic steatosis
2096	1771: Decrease, ATP pool	350: Increase, Mortality	Apr 30, 2020	Apr 30, 2020	2 AOPs 328: Excessive reactive oxygen species production leading to mortality (2) 329: Excessive reactive oxygen species production leading to mortality (3)
2120	1771: Decrease, ATP pool	1775: Increase, Oocyte apoptosis	May 8, 2020	May 8, 2020	None
2121	1771: Decrease, ATP pool	1607: Increase, Necrosis	May 8, 2020	May 8, 2020	None
2179	1771: Decrease, ATP pool	1810: Decrease, ATPase activity	Nov 2, 2020	Nov 2, 2020	None
2204	1771: Decrease, ATP pool	1821: Decrease, Cell proliferation	Nov 12, 2020	Dec 7, 2020	6 AOPs 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 286: Mitochondrial complex III antagonism leading to growth inhibition (1) 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation 326: Reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation 332: Reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation
2209	1771: Decrease, ATP pool	1366: Decrease, Oogenesis	Nov 25, 2020	Nov 25, 2020	None
2214	1771: Decrease, ATP pool	1825: Increase, Cell death	Dec 4, 2020	Dec 4, 2020	1 AOP 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
2216	1771: Decrease, ATP pool	1312: Increase, Fatty acid β-oxidation	Dec 4, 2020	Dec 4, 2020	None
2768	1771: Decrease, ATP pool	55: Cell injury/death	Sep 27, 2022	Jun 23, 2026	5 AOPs 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 331: Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 333: Reactive oxygen species leading to growth inhibition via protein oxidation and cell death
2786	1771: Decrease, ATP pool	1562: Decreased Na/K ATPase activity	Oct 19, 2022	Oct 19, 2022	1 AOP 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity
3603	1771: Decrease, ATP pool	2327: Decrease, Cell growth	Aug 21, 2025	Aug 21, 2025	1 AOP 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth
3677	1771: Decrease, ATP pool	2384: Decrease, Vascular integrity	Oct 30, 2025	Oct 30, 2025	1 AOP 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate
1937	1614: Decrease, AR activation	1615: Impaired inguinoscrotal phase	Jun 3, 2019	Jun 3, 2019	1 AOP 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
2124	1614: Decrease, AR activation	286: Altered, Transcription of genes by the AR	May 11, 2020	Mar 20, 2026	10 AOPs 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 345: Androgen receptor (AR) antagonism leading to decreased fertility in females 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring
2820	1614: Decrease, AR activation	1688: AGD, decreased	Dec 22, 2022	Feb 4, 2026	3 AOPs 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
2828	1614: Decrease, AR activation	2082: Hypospadias	Jan 11, 2023	Mar 20, 2026	3 AOPs 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring
3348	1614: Decrease, AR activation	1786: nipple retention, increased	Sep 26, 2024	Mar 20, 2026	3 AOPs 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring
3451	1614: Decrease, AR activation	743: Decreased, Testosterone binding to androgen receptor (hypothalamus)	Dec 23, 2024	Dec 23, 2024	1 AOP 111: Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
961	914: Decreased ciliated cell apoptosis	919: Occurrence, Transdifferentiation of ciliated epithelial cells	Nov 29, 2016	Aug 25, 2021	None
2470	914: Decreased ciliated cell apoptosis	920: Goblet cell metaplasia	Aug 25, 2021	Aug 25, 2021	None
1664	1472: Decrease, ATP production	1473: Decrease, Chlorophyll synthesis	Oct 10, 2017	Oct 10, 2017	1 AOP 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
2341	1472: Decrease, ATP production	1479: Decrease, Leaf development	Apr 11, 2021	Apr 11, 2021	1 AOP 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis

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