AOP-Wiki

API

All KERs

Showing 1451 to 1475 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1232	1171: Increase, Clonal Expansion of Altered Hepatic Foci	719: Increase, hepatocellular adenomas and carcinomas	Nov 29, 2016	Dec 3, 2016	1 AOP 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
3056	2195: Increase, CNS Neural cell death	2196: Decrease, elavl3	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
3057	2195: Increase, CNS Neural cell death	2197: Decrease, sox10	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
3058	2195: Increase, CNS Neural cell death	2198: Decrease, mbp	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
3501	2195: Increase, CNS Neural cell death	2121: decreased, IQ	Mar 2, 2025	Mar 2, 2025	1 AOP 569: Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway
82	68: Increase, Collagen accumulation	344: Increase, Liver fibrosis	Nov 29, 2016	Dec 5, 2018	8 AOPs 38: Protein Alkylation leading to Liver Fibrosis 144: Endocytic lysosomal uptake leading to liver fibrosis 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
1629	68: Increase, Collagen accumulation	1458: Pulmonary fibrosis	Jul 26, 2017	May 18, 2023	2 AOPs 241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
2139	68: Increase, Collagen accumulation	1276: Lung fibrosis	May 15, 2020	May 15, 2020	2 AOPs 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 319: Binding to ACE2 leading to lung fibrosis
1450	1334: Increase, cortisone	122: Increase, GR activation	Apr 14, 2017	Apr 14, 2017	1 AOP 214: Network of SSRIs (selective serotonin reuptake inhibitors)
1351	1269: Increase, COX-2 expression	317: Altered, Cardiovascular development/function	Feb 9, 2017	Mar 28, 2018	1 AOP 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2
2184	1812: Increase, Cyt c release	1365: Increase, Apoptosis	Nov 2, 2020	Nov 2, 2020	None
3050	1812: Increase, Cyt c release	2188: Caspase activation	Sep 14, 2023	Sep 14, 2023	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
2764	2064: Increase, Cytosolic Ca	1825: Increase, Cell death	Sep 13, 2022	Sep 13, 2022	None
2766	2064: Increase, Cytosolic Ca	55: Cell injury/death	Sep 27, 2022	Sep 27, 2022	1 AOP 265: Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium
1693	1305: Increase, cytosolic fatty acid	1489: Increase, Steatohepatitis	Nov 13, 2017	Nov 13, 2017	None
1694	1305: Increase, cytosolic fatty acid	459: Increase, Liver steatosis	Nov 14, 2017	Nov 14, 2017	1 AOP 213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
766	768: Increase, Cytotoxicity	719: Increase, hepatocellular adenomas and carcinomas	Nov 29, 2016	Dec 3, 2016	1 AOP 108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
887	768: Increase, Cytotoxicity	868: Increase, Tissue Degeneration, Necrosis & Atrophy	Nov 29, 2016	Nov 29, 2016	1 AOP 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
767	770: Increase, Cytotoxicity (club cells)	733: Increase, Necrosis (terminal bronchiolar cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
777	776: Increase, Cytotoxicity (corneal cells)	777: Increase, Inflammation (corneal cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 114: HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
780	780: Increase, Cytotoxicity (epithelial cells)	149: Increase, Inflammation	Nov 29, 2016	Dec 3, 2016	1 AOP 115: Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
2659	780: Increase, Cytotoxicity (epithelial cells)	1115: Increase, ROS	May 25, 2022	May 25, 2022	1 AOP 451: Interaction with lung resident cell membrane components leads to lung cancer
2664	780: Increase, Cytotoxicity (epithelial cells)	2006: Secondary genotoxicity	May 25, 2022	May 25, 2022	1 AOP 451: Interaction with lung resident cell membrane components leads to lung cancer
788	786: Increase, Cytotoxicity (hepatocytes)	787: Increase, Regenerative cell proliferation (hepatocytes)	Nov 29, 2016	Dec 3, 2016	1 AOP 118: Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)
708	709: Increase, Cytotoxicity (renal tubular cell)	710: Increase, Regenerative cell proliferation (tubular epithelial cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)

Key Event Relationships (KERs)

All KERs