AOPs

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Showing 1 to 3 of 3 AOPs in Title Search Results

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Showing 1 to 25 of 29 Fulltext Results
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ID Title Point of Contact License MIE AO OECD Status OECD Project
3 Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Andrea Terron BY-SA 888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) 896: Parkinsonian motor deficits WPHA/WNT Endorsed 1.33
17 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory Marie-Gabrielle Zurich BY-SA 1487: Binding, Thiol/seleno-proteins involved in protection against oxidative stress 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.13
31 Oxidation of iron in hemoglobin leading to hematotoxicity Undefined Open for adoption 213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III) 321: N/A, Cyanosis occurs Under Development 1.16
37 PPARĪ± activation leading to hepatocellular adenomas and carcinomas in rodents Chris Corton BY-SA 227: Activation, PPARĪ± 719: Increase, hepatocellular adenomas and carcinomas Under Development 1.17
39 Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response Jessica Ponder BY-SA 396: Covalent Binding, Protein 313: Increase, Allergic Respiratory Hypersensitivity Response Under Development 1.20
46 AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Ted Simon BY-SA 373: Formation, Pro-mutagenic DNA Adducts 378: Tumorigenesis, Hepatocellular carcinoma Under Review 1.8
144 Endocytic lysosomal uptake leading to liver fibrosis Marina Kuburic BY-SA 1539: Endocytotic lysosomal uptake 344: Increase, Liver fibrosis Under Review 1.47
149 Peptide Oxidation Leading to Hypertension Frazer Lowe BY-SA 209: Peptide Oxidation 952: Hypertension Under Development 1.50
205 AOP from chemical insult to cell death Mathieu Vinken BY-SA
209 Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Jinhee Choi All rights reserved None 1291: Hepatotoxicity
220 Cyp2E1 Activation Leading to Liver Cancer Francina Webster BY-SA 1391: Activation of Cyp2E1 1395: Liver Cancer WPHA/WNT Endorsed 1.24
260 CYP2E1 activation and formation of protein adducts leading to neurodegeneration Jelle Broeders BY-SA 1514: Neurodegeneration
293 Increased DNA damage leading to increased risk of breast cancer Jessica Helm BY-SA 1194: Increase, DNA damage Under Development 1.80
294 Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer Jessica Helm BY-SA 1632: Increase in reactive oxygen and nitrogen species (RONS) Under Development 1.80
296 Oxidative DNA damage leading to chromosomal aberrations and mutations Carole Yauk BY-SA 1634: Increase, Oxidative DNA damage WPHA/WNT Endorsed 1.76
413 Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure Carmel Mothersill BY-SA 926: Oxidation, Glutathione (To be considered with MIE) 351: Increased Mortality
451 Interaction with lung resident cell membrane components leads to lung cancer Penny Nymark BY-SA 1495: Substance interaction with the lung resident cell membrane components 1670: Lung cancer
459 AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals Prakash Patel Open for adoption 18: Activation, AhR 402: Cognitive function, decreased
462 Activation of reactive oxygen species leading the atherosclerosis Hiromi Ohara BY-SA 1115: Increase, Reactive oxygen species None
470 Deposition of energy leads to abnormal vascular remodeling Vinita Chauhan BY-SA 1686: Deposition of Energy 2069: Occurrence, Abnormal Vascular Remodeling WPHA/WNT Endorsed 1.89
472 DNA adduct formation leading to kidney failure Manoe Janssen BY-SA 373: Formation, Pro-mutagenic DNA Adducts 759: Increased, Kidney Failure
478 Deposition of energy leading to occurrence of cataracts Vinita Chauhan BY-SA 1686: Deposition of Energy 2083: Occurrence of Cataracts WPHA/WNT Endorsed 1.89
482 Deposition of energy leading to occurrence of bone loss Vinita Chauhan BY-SA 1686: Deposition of Energy 2091: Occurrence, Bone Loss WPHA/WNT Endorsed 1.89
483 Deposition of Energy Leading to Learning and Memory Impairment Vinita Chauhan BY-SA 1686: Deposition of Energy 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.89
492 Glutathione conjugation leading to reproductive dysfunction via oxidative stress Leonardo Vieira All rights reserved 2131: Conjugation, GSH 406: decreased, Fertility