AOPs

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Showing 401 to 425 of 595 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
230 presynaptic neuron 1 activation to epilepsy Lyle Burgoon Open for adoption 1349: Activated, presynaptic neuron 1 1363: Increased, epilepsy
229 Helicobacter pylori to gastric ulcer Lyle Burgoon Open for adoption 1412: Helicobacter pylori infection 1385: Activated, gastric ulcer formation
228 NSAID induced PTGS2 inactivation to gastric ulcer Lyle Burgoon Open for adoption 1408: Reduced, PTGS2 function 1385: Activated, gastric ulcer formation
227 NSAID induced PTGS1 inactivation to gastric ulcer Lyle Burgoon Open for adoption 1402: Reduced, PTGS1 function 1385: Activated, gastric ulcer formation
226 SSRI (Selective serotonin reuptake inhibitor) to hypertension Lyle Burgoon Open for adoption 1317: Decreased, serotonin transporter activity 1343: Increase, hypertension
225 Serotonin transporter activation to agitation Lyle Burgoon Open for adoption None 1345: Increased, agitation
224 Serotonin transporter activation to depression Lyle Burgoon Open for adoption 1397: Increased, serotonin transporter activity 1346: Increased, depression
223 Serotonin transporter activation to seizure Lyle Burgoon Open for adoption 1397: Increased, serotonin transporter activity 1344: Increased, seizure
222 Mental stress to agitation Lyle Burgoon Open for adoption 1396: Increased, glucocorticoid receptor activity 1345: Increased, agitation
221 Mental stress to depression Lyle Burgoon Open for adoption 1396: Increased, glucocorticoid receptor activity 1346: Increased, depression
220 Cyp2E1 Activation Leading to Liver Cancer Francina Webster BY-SA 1391: Activation of Cyp2E1 1395: Liver Cancer WPHA/WNT Endorsed 1.24
219 Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior Florence Pagé-Larivière BY-SA 1386: CYP7B activity, inhibition 360: Decrease, Population growth rate
218 Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity Florence Pagé-Larivière BY-SA 1386: CYP7B activity, inhibition 360: Decrease, Population growth rate
217 Gastric ulcer formation Lyle Burgoon Open for adoption None
216 Deposition of energy leading to population decline via DNA strand breaks and follicular atresia Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
215 Molecular events lead to epilepsy Lyle Burgoon Open for adoption None
214 Network of SSRIs (selective serotonin reuptake inhibitors) Lyle Burgoon Open for adoption None
213 Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) Lyle Burgoon Open for adoption 1490: Inhibition, Fatty Acid Beta Oxidation 1489: Increase, Steatohepatitis
212 Histone deacetylase inhibition leading to testicular atrophy Shihori Tanabe BY-SA 1502: Histone deacetylase inhibition 1506: Testicular atrophy WPHA/WNT Endorsed 1.52
211 Handbook development AOP Dan Villeneuve BY-SA None None
210 Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building Jinhee Choi BY-SA None 1277: Reproductive failure
209 Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Jinhee Choi BY-SA None 1291: Hepatotoxicity
208 Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure Jinhee Choi BY-SA None 1277: Reproductive failure
207 NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans Jinhee Choi BY-SA 1174: Activation, NADPH Oxidase 1277: Reproductive failure
206 Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Jinhee Choi BY-SA 1270: Inactivation of PPARγ 1276: Lung fibrosis Under Development 1.54