AOPs

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Showing 401 to 425 of 579 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
214 Network of SSRIs (selective serotonin reuptake inhibitors) Lyle Burgoon Open for adoption None
213 Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) Lyle Burgoon Open for adoption 1490: Inhibition, Fatty Acid Beta Oxidation 1489: Increase, Steatohepatitis
212 Histone deacetylase inhibition leading to testicular atrophy Shihori Tanabe BY-SA 1502: Histone deacetylase inhibition 1506: Testicular atrophy WPHA/WNT Endorsed 1.52
211 Handbook development AOP Dan Villeneuve BY-SA None None
210 Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building Jinhee Choi All rights reserved None 1277: Reproductive failure
209 Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Jinhee Choi All rights reserved None 1291: Hepatotoxicity
208 Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure Jinhee Choi All rights reserved None 1277: Reproductive failure
207 NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans Jinhee Choi All rights reserved 1174: Activation, NADPH Oxidase 1277: Reproductive failure
206 Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Jinhee Choi All rights reserved 1270: Inactivation of PPARγ 1276: Lung fibrosis Under Development 1.54
205 AOP from chemical insult to cell death Mathieu Vinken BY-SA
204 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase Kellie Fay BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
203 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline Kellie Fay BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
202 Inhibitor binding to topoisomerase II leading to infant leukaemia Andrea Terron BY-SA 1252: Binding to (interferes with) topoisomerase II enzyme 1254: Infant leukaemia WPHA/WNT Endorsed 1.53
201 Juvenile hormone receptor agonism leading to male offspring induction associated population decline Knut Erik Tollefsen BY-SA 1205: Activation, Juvenile hormone receptor
200 Estrogen receptor activation leading to breast cancer Molly M Morgan Open for adoption 111: Agonism, Estrogen receptor 1193: N/A, Breast Cancer
199 ER mediated breast cancer AOP Molly M Morgan BY-SA None None
197 Sodium channel (Nav1.1) inhibition leading to population decline Kellie Fay BY-SA 584: Inhibition, sodium channel None
196 Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation Jeanelle Martinez BY-SA 1215: TRPA1 activation, TRPA1 Receptor
195 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase Kellie Fay BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 1164: Increased, Population
194 Hepatic nuclear receptor activation leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1157: Activation, Hepatic nuclear receptor(s) 1101: Altered, Amphibian metamorphosis
193 Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1156: Inhibition, Dual oxidase 1101: Altered, Amphibian metamorphosis
192 Pendrin inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1155: Inhibition, Pendrin 1101: Altered, Amphibian metamorphosis
191 Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1153: Inhibition, Deiodinase 3 1101: Altered, Amphibian metamorphosis
190 Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1002: Inhibition, Deiodinase 2 1101: Altered, Amphibian metamorphosis
189 Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1009: Inhibition, Deiodinase 1 1101: Altered, Amphibian metamorphosis