AOPs

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Showing 476 to 500 of 579 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
123 Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Dalma Martinovic-Weigelt BY-SA 801: modulation, Unknown
122 Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation Dalma Martinovic-Weigelt BY-SA 798: Inhibition, Prolyl hydroxylases
121 Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) Charles Wood BY-SA 793: Increase, Urinary bladder calculi 797: Increase, Adenomas/carcinomas (urothelial)
120 Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) Charles Wood BY-SA 1617: Inhibition, 5α-reductase 745: Increase, Leydig cell tumors
119 Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood BY-SA 279: Thyroperoxidase, Inhibition 741: Increase, Adenomas/carcinomas (follicular cell)
118 Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood BY-SA 786: Increase, Cytotoxicity (hepatocytes) 719: Increase, hepatocellular adenomas and carcinomas
117 Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Open for adoption 25: Agonism, Androgen receptor 719: Increase, hepatocellular adenomas and carcinomas Under Development 1.26
116 Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood BY-SA 783: Increase, Cytotoxicity (tubular epithelial cells) 713: Increase, Adenomas/carcinomas (renal tubular)
115 Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) Charles Wood BY-SA 780: Increase, Cytotoxicity (epithelial cells) 779: Increase, Papillomas/carcinomas (squamous cells)
114 HPPD inhibition leading to corneal papillomas and carcinomas (in rat) Charles Wood BY-SA 766: Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme 779: Increase, Papillomas/carcinomas (squamous cells)
113 Glutamate-gated chloride channel activation leading to acute mortality Helen Poynton BY-SA 760: Activation, Glutamate-gated chloride channel
112 Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) Charles Wood BY-SA 746: Increase, Dopaminergic activity 773: Increase, Endometrial adenocarcinomas
111 Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) Charles Wood BY-SA 1614: Decrease, androgen receptor activation 745: Increase, Leydig cell tumors
110 Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood BY-SA 424: Inhibition, Na+/I- symporter (NIS) 741: Increase, Adenomas/carcinomas (follicular cell)
109 Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) Charles Wood BY-SA 770: Increase, Cytotoxicity (club cells) 736: Increase, Adenomas/carcinomas (bronchioloalveolar)
108 Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood BY-SA 724: Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme 719: Increase, hepatocellular adenomas and carcinomas
107 Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Kristin Lichti-Kaiser BY-SA 715: Activation, Constitutive androstane receptor 719: Increase, hepatocellular adenomas and carcinomas Under Review 1.17
106 Chemical binding to tubulin in oocytes leading to aneuploid offspring Francesco Marchetti BY-SA 718: Binding, Tubulin 728: Increase, Aneuploid offspring Under Review 1.11
105 Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood BY-SA 714: Increased, Binding of chemicals to 2u (serum) 713: Increase, Adenomas/carcinomas (renal tubular)
104 Altered ion channel activity leading impaired heart function Undefined BY-SA 697: impaired, ion channels 351: Increased Mortality
103 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint Dalma Martinovic-Weigelt BY-SA 79: Inhibition, Cyclooxygenase activity
102 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition Dalma Martinovic-Weigelt BY-SA 79: Inhibition, Cyclooxygenase activity
101 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release Dalma Martinovic-Weigelt BY-SA 79: Inhibition, Cyclooxygenase activity
100 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior Dalma Martinovic-Weigelt BY-SA 79: Inhibition, Cyclooxygenase activity
99 Histamine (H2) receptor antagonism leading to reduced survival Kellie Fay BY-SA 638: Antagonism, Histamine Receptor (H2)