AOPs

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Showing 476 to 500 of 595 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
152 Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity Kristie Sullivan BY-SA 957: Binding, Transthyretin in serum 402: Cognitive function, decreased Under Development 1.41
151 AhR activation leading to preeclampsia Sabrina Tait BY-SA 18: Activation, AhR 1893: increase, Preeclampsia Under Development 1.42
150 Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF Amani Farhat BY-SA 18: Activation, AhR 947: Increase, Early Life Stage Mortality WPHA/WNT Endorsed 1.7
149 Peptide Oxidation Leading to Hypertension Frazer Lowe BY-SA 209: Peptide Oxidation 952: Hypertension Under Development 1.50
148 EGFR Activation Leading to Decreased Lung Function Karsta Luettich BY-SA 941: Activation, EGFR 1250: Decrease, Lung function Under Development 1.51
146 Estrogen Receptor Activation and Female Precocious Puberty Undefined Open for adoption None None
144 Endocytic lysosomal uptake leading to liver fibrosis Marina Kuburic BY-SA 1539: Endocytotic lysosomal uptake 344: Increase, Liver fibrosis Under Review 1.47
139 Alkylation of DNA leading to cancer 1 Carole Yauk Open for adoption 97: Alkylation, DNA 885: Increase, Cancer
138 Organic anion transporter (OAT1) inhibition leading to renal failure and mortality Kellie Fay BY-SA 877: Inhibition, organic anion transporter 1 (OAT1)
136 Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors Undefined BY-SA 867: Decrease, Intracellular pH 872: Increase, Site of Contact Nasal Tumors Under Review 2.7
134 Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Mary Gilbert BY-SA 424: Inhibition, Na+/I- symporter (NIS) 402: Cognitive function, decreased
131 Aryl hydrocarbon receptor activation leading to uroporphyria Amani Farhat BY-SA 18: Activation, AhR 369: Uroporphyria WPHA/WNT Endorsed 1.7
130 Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity Jung-Hwa Oh BY-SA 828: Inhibition, Phospholipase A 840: Formation, Liver fibrosis Under Development 1.39
128 Kidney dysfunction by decreased thyroid hormone Jung-Hwa Oh BY-SA 277: Thyroid hormone synthesis, Decreased 814: Occurrence, Kidney toxicity Under Development 1.40
126 Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation Undefined BY-SA 849: Inhibition, Antgonism of NE receptor 527: Decreased, Decreased fecundity
124 HMG-CoA reductase inhibition leading to decreased fertility Kellie Fay BY-SA 804: Inhibition, HMG-CoA reductase 330: Decrease, Fertility
123 Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Dalma Martinovic-Weigelt BY-SA 801: modulation, Unknown
122 Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation Dalma Martinovic-Weigelt BY-SA 798: Inhibition, Prolyl hydroxylases
121 Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) Charles Wood BY-SA 793: Increase, Urinary bladder calculi 797: Increase, Adenomas/carcinomas (urothelial)
120 Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) Charles Wood BY-SA 1617: Inhibition, 5α-reductase 745: Increase, Leydig cell tumors
119 Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood BY-SA 279: Thyroperoxidase, Inhibition 741: Increase, Adenomas/carcinomas (follicular cell)
118 Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood BY-SA 786: Increase, Cytotoxicity (hepatocytes) 719: Increase, hepatocellular adenomas and carcinomas
117 Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Open for adoption 25: Agonism, Androgen receptor 719: Increase, hepatocellular adenomas and carcinomas Under Development 1.26
116 Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood BY-SA 783: Increase, Cytotoxicity (tubular epithelial cells) 713: Increase, Adenomas/carcinomas (renal tubular)
115 Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) Charles Wood BY-SA 780: Increase, Cytotoxicity (epithelial cells) 779: Increase, Papillomas/carcinomas (squamous cells)