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Showing 251 to 275 of 574 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
298 Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer Shihori Tanabe BY-SA 1115: Increase, Reactive oxygen species 1651: Treatment-resistant gastric cancer Under Review 1.58
299 Deposition of energy leading to population decline via DNA oxidation and follicular atresia You Song BY-SA 1686: Deposition of Energy
300 Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton BY-SA 1656: Antagonism, Thyroid Receptor 402: Cognitive function, decreased Under Development 1.84
301 Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis Young Jun Kim BY-SA 1657: Inhibition of cystathionine beta-synthase 1667: Impaired,anterior-posterior axis development
302 Lung surfactant function inhibition leading to decreased lung function Jorid Birkelund Sørli BY-SA 1672: Inhibition of lung surfactant function 1250: Decrease, Lung function Under Development 1.87
303 Frustrated phagocytosis-induced lung cancer Carole Seidel BY-SA 1668: Frustrated phagocytosis 1670: Lung cancer Under Development 1.86
304 TBX1 inhibition leading to congenital cardiac conotruncal anomalies Jinsoo Lee All rights reserved 1680: Inhibition, TBX1 1685: Anomalies, Congenital cardiac conotruncal
305 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen BY-SA 1617: Inhibition, 5α-reductase 1688: anogenital distance (AGD), decreased Under Review 1.90
306 Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen BY-SA 26: Antagonism, Androgen receptor 1688: anogenital distance (AGD), decreased Under Review 1.90
307 Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen BY-SA None 1688: anogenital distance (AGD), decreased Under Review 1.90
309 Luteinizing hormone receptor antagonism leading to reproductive dysfunction Young Jun Kim BY-SA 1691: Antagonism,LH receptor 679: Decline, Population trajectory
310 Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR Jon Doering BY-SA 18: Activation, AhR
311 Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis You Song BY-SA 1686: Deposition of Energy
312 Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​ Kristie Sullivan BY-SA 12: Acetylcholinesterase (AchE) Inhibition
313 Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease Hiroyuki Komatsu BY-SA 1706: Stimulation, TLR7/8 1709: Psoriatic skin disease Under Development 1.75
314 Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) Yasuharu Otsubo BY-SA 1710: Binding to estrogen receptor (ER)-α in immune cells 1714: Exacerbation of systemic lupus erythematosus (SLE) Under Development 1.73
315 Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response Yasuhiro Yoshida BY-SA 1715: Inhibition of JAK3 1719: Impairment of T-cell dependent antibody response Under Development 1.74
316 Trypsin inhibition leading to pancreatic acinar cell tumors Shigeru Hisada BY-SA 1720: Trypsin inhibition 1725: Pancreatic acinar cell tumors Under Development 1.60
318 Glucocorticoid Receptor activation leading to hepatic steatosis Chander K. Negi BY-SA 122: Increase, Glucocorticoid receptor activation 459: Increase, Liver steatosis
319 Binding to ACE2 leading to lung fibrosis Young Jun Kim BY-SA 1740: Induced dysregulation of ACE2 1276: Lung fibrosis Under Development 1.96
320 Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality Young Jun Kim BY-SA 1739: Binding to ACE2 351: Increased Mortality Under Development 1.96
321 Reduced environmental pH leading to thinner shells in Mytilus edulis James Ducker BY-SA None None
322 Alkylation of DNA leading to reduced sperm count Carole Yauk BY-SA 97: Alkylation, DNA 1757: Reduce, Sperm count
323 PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone Jennifer Olker BY-SA 227: Activation, PPARα
324 Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and cell death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth