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ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

116	Activation, FAS Short Name Activation, FAS	1	Molecular	Nov 29, 2016	Sep 16, 2017	34: LXR activation leading to hepatic steatosis
195	Inhibition, NMDARs Short Name Inhibition, NMDARs	1	Molecular	Nov 29, 2016	Sep 16, 2017	3 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 522: Estrogen antagonism leading to increased risk of autism-like behavior
201	Binding of antagonist, NMDA receptors Short Name Binding of antagonist, NMDA receptors	0	Molecular	Nov 29, 2016	Jun 13, 2018	2 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
209	Peptide Oxidation Short Name Peptide Oxidation	1	Molecular	Nov 29, 2016	Nov 13, 2017	4 AOPs 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) 108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) 149: Peptide Oxidation Leading to Hypertension 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
221	Reduction, Plasma vitellogenin concentrations Short Name	1	Organ	Nov 29, 2016	May 27, 2026	11 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 289: Inhibition of 5α-reductase leading to decreased population growth rate via impaired fecundity in female fish 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
258	Activation, SCD-1 Short Name Activation, SCD-1	1	Molecular	Nov 29, 2016	Sep 16, 2017	34: LXR activation leading to hepatic steatosis
285	Reduction, Vitellogenin synthesis in liver Short Name	2	Tissue	Nov 29, 2016	May 27, 2026	7 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production
309	Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development Short Name	3	Cellular	Nov 29, 2016	May 27, 2026	9 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
387	Binding of agonist, NMDARs Short Name Binding of agonist, NMDARs	0	Molecular	Nov 29, 2016	Nov 29, 2016	None
682	Generation, Amplified excitatory postsynaptic potential (EPSP) Short Name	1	Cellular	Nov 29, 2016	May 18, 2018	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
718	Binding, Tubulin Short Name Binding, Tubulin	2	Molecular	Nov 29, 2016	Apr 20, 2021	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
827	sensitisation, skin Short Name sensitisation, skin	0	Organ	Nov 29, 2016	Nov 29, 2016	40: Covalent Protein binding leading to Skin Sensitisation
846	Accumulation, Highly carboxylated porphyrins Short Name	1	Organ	Nov 29, 2016	May 7, 2018	131: Aryl hydrocarbon receptor activation leading to uroporphyria
861	Decreased, Ketogenesis (production of ketone bodies) Short Name	1	Cellular	Nov 29, 2016	Apr 30, 2019	6: Antagonist binding to PPARα leading to body-weight loss
875	Binding of agonist, Ionotropic glutamate receptors Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
902	Inflammation, Liver Short Name Inflammation, Liver	1	Organ	Nov 29, 2016	Sep 16, 2017	4 AOPs 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 615: Suppression of Keap1 cysteine oxidation leading to liver inflammation 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
932	KE4 : Uncoupling, eNOS Short Name Uncoupling, eNOS	1	Cellular	Nov 29, 2016	Nov 9, 2017	2 AOPs 149: Peptide Oxidation Leading to Hypertension 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
934	KE3 : Decrease, Tetrahydrobiopterin Short Name Decrease, Tetrahydrobiopterin	1	Cellular	Nov 29, 2016	Nov 9, 2017	149: Peptide Oxidation Leading to Hypertension
957	Binding, Transthyretin in serum Short Name Binding, Transthyretin in serum	1	Molecular	Nov 29, 2016	Apr 22, 2026	2 AOPs 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis
981	Reduction, NFAT/AP-1 complex formation Short Name Reduction, NFAT/AP-1 complex formation	2	Cellular	Nov 29, 2016	Jun 27, 2021	154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
1202	Suppression, IL-2 and IL-4 production Short Name Suppression, IL-2 and IL-4 production	2	Cellular	Nov 29, 2016	Jun 27, 2021	154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
1386	CYP7B activity, inhibition Short Name CYP7B activity, inhibition	0	Molecular	May 2, 2017	May 17, 2017	2 AOPs 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
1445	Increase, Lipid peroxidation Short Name Increase, LPO	1	Molecular	Jun 29, 2017	Jun 23, 2026	8 AOPs 329: Excessive reactive oxygen species production leading to mortality (3) 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress 521: Essential element imbalance leads to reproductive failure via oxidative stress 331: Increase in reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 615: Suppression of Keap1 cysteine oxidation leading to liver inflammation 326: Increase in reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation 647: Increase in reactive oxygen species leading to growth inhibition via increased caspase activation
1511	Lipid Peroxidation Short Name Lipid Peroxidation	0	Molecular	Apr 4, 2018	Apr 4, 2018	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
1634	Increase, Oxidative DNA damage Short Name Increase, Oxidative DNA damage	1	Molecular	May 19, 2019	Sep 2, 2026	8 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis 478: Deposition of energy leading to occurrence of cataracts 330: Excessive reactive oxygen species production leading to mortality (4) 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage 324: Increase in reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption 325: Increase in reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death

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