AOPs

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Showing 351 to 375 of 579 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
276 Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome Marvin Martens BY-SA 888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) 1564: Chemical induced Fanconi syndrome
275 Histone deacetylase inhibition leads to neural tube defects Marvin Martens BY-SA 1502: Histone deacetylase inhibition 1561: Neural tube defects
274 Histone deacetylase inhibition leads to impeded craniofacial development Marvin Martens BY-SA 1502: Histone deacetylase inhibition 1559: Facial cartilage structures are reduced in size and morphologically distorted
273 Mitochondrial complex inhibition leading to liver injury Wanda van der Stel BY-SA
272 Deposition of energy leading to lung cancer Vinita Chauhan BY-SA 1686: Deposition of Energy 1556: Increase, lung cancer WPHA/WNT Endorsed 1.56
271 Inhibition of thyroid peroxidase leading to impaired fertility in fish June-Woo Park BY-SA 279: Thyroperoxidase, Inhibition 78: Reduction, Cumulative fecundity and spawning Under Development 1.59
270 Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity Christopher Goodchild All rights reserved None None
269 Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development Christopher Goodchild BY-SA None None
268 Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
267 Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
266 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
265 Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
264 Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
263 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth WPHA/WNT Endorsed 1.92
262 L-type calcium channel blockade leading to the disruption of cardiac electrophysiology Luigi Margiotta-Casaluci All rights reserved None None Under Development 1.45
261 L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility Luigi Margiotta-Casaluci All rights reserved 1529: Blockade, L-Type Calcium Channels 1535: Heart failure Under Development 1.45
260 CYP2E1 activation and formation of protein adducts leading to neurodegeneration Jelle Broeders BY-SA 1514: Neurodegeneration
259 Sensitization induction of the intestinal tract by food proteins Erwin L Roggen BY-SA None None
258 Renal protein alkylation leading to kidney toxicity Angela Mally BY-SA 244: Alkylation, Protein 814: Occurrence, Kidney toxicity Under Development 1.43
257 Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity Angela Mally BY-SA 1486: Binding of substrate, endocytic receptor 814: Occurrence, Kidney toxicity Under Development 1.43
256 Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity Angela Mally BY-SA 1481: Inhibition of mitochondrial DNA polymerase gamma (Pol gamma) 814: Occurrence, Kidney toxicity Under Development 1.43
245 Reduction in photophosphorylation leading to growth inhibition in aquatic plants Knut Erik Tollefsen BY-SA 1471: Increase, Uncoupling of photophosphorylation 1521: Decrease, Growth
242 Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Stefan Scholz Open for adoption 1462: Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts
241 Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Marvin Martens BY-SA 1468: Activation, Latent Transforming Growth Factor Beta 1 1458: Pulmonary fibrosis
240 DNA Adducts Leading to Liver Hemangiosarcoma Undefined BY-SA None None