AOPs

OECD View API
Toggle for API info
The API endpoint defaults to 25 results per page, but you can adjust this by changing the per_page parameter in the URL.
Searches both title and fulltext content
Takes you to the requested AOP
Clear Search Terms Clears search terms and filters

Showing 351 to 375 of 588 AOPs

Clear Table Filters
ID Title Point of Contact License MIE AO OECD Status OECD Project
285 Inhibition of N-linked glycosylation leads to liver injury Marvin Martens BY-SA 1604: Inhibition of N-linked glycosylation 1549: Liver Injury
284 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease Frederic Y. Bois BY-SA 1487: Binding, Thiol/seleno-proteins involved in protection against oxidative stress 1603: Chronic kidney disease
283 L-type calcium channel blockade leading to hypotension Luigi Margiotta-Casaluci BY-SA None None Under Development 1.45
282 Adverse outcome pathway on photochemical toxicity initiated by light exposure Satomi Onoue BY-SA 1115: Increase, Reactive oxygen species 1599: Inflamatory events in light-exposed tissues Under Review 1.49
281 Acetylcholinesterase Inhibition Leading to Neurodegeneration Karen Watanabe BY-SA 12: Acetylcholinesterase (AchE) Inhibition 352: N/A, Neurodegeneration
280 α-diketone-induced bronchiolitis obliterans Marvin Martens BY-SA 1584: Interaction of α-diketones with arginine residues 1588: Bronchiolitis obliterans
279 Microtubule interacting drugs lead to peripheral neuropathy Marvin Martens BY-SA 1580: Binding of microtubule stabilizing agents (MSA) to microtubules 1583: Sensory axonal peripheral neuropathy
278 IKK complex inhibition leading to liver injury Nanette Vrijenhoek BY-SA 1574: Inhibition, IKK complex
277 Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response Takao Ashikaga BY-SA 1700: Impaired IL-1R1 signaling in T cell 984: Impairment, T-cell dependent antibody response WPHA/WNT Endorsed 1.48
276 Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome Marvin Martens BY-SA 888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) 1564: Chemical induced Fanconi syndrome
275 Histone deacetylase inhibition leads to neural tube defects Marvin Martens BY-SA 1502: Histone deacetylase inhibition 1561: Neural tube defects
274 Histone deacetylase inhibition leads to impeded craniofacial development Marvin Martens BY-SA 1502: Histone deacetylase inhibition 1559: Facial cartilage structures are reduced in size and morphologically distorted
273 Mitochondrial complex inhibition leading to liver injury Wanda van der Stel BY-SA
272 Deposition of energy leading to lung cancer Vinita Chauhan BY-SA 1686: Deposition of Energy 1556: Increase, lung cancer WPHA/WNT Endorsed 1.56
271 Inhibition of thyroid peroxidase leading to impaired fertility in fish June-Woo Park BY-SA 279: Thyroperoxidase, Inhibition 78: Reduction, Cumulative fecundity and spawning Under Development 1.59
270 Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity Christopher Goodchild BY-SA None None
269 Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development Christopher Goodchild BY-SA None None
268 Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
267 Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
266 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
265 Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
264 Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
263 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth WPHA/WNT Endorsed 1.92
262 L-type calcium channel blockade leading to the disruption of cardiac electrophysiology Luigi Margiotta-Casaluci BY-SA None None Under Development 1.45
261 L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility Luigi Margiotta-Casaluci BY-SA 1529: Blockade, L-Type Calcium Channels 1535: Heart failure Under Development 1.45