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Showing 1726 to 1750 of 3164 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2718	1825: Increase, Cell death	188: Neuroinflammation	Jul 25, 2022	Jul 25, 2022	None
2760	1825: Increase, Cell death	1496: Increased proinflammatory mediators	Sep 1, 2022	Sep 1, 2022	1 AOP 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
2842	1825: Increase, Cell death	2089: Altered Bone Cell Homeostasis	Jan 25, 2023	Nov 6, 2024	1 AOP 482: Deposition of energy leading to occurrence of bone loss
2863	1825: Increase, Cell death	758: Hippocampal Physiology, Altered	Apr 3, 2023	Apr 3, 2023	None
3504	1825: Increase, Cell death	2312: Increased, nasal lesions	Mar 5, 2025	Mar 19, 2025	1 AOP 368: Cytochrome oxidase inhibition leading to increased nasal lesions
3507	1825: Increase, Cell death	2316: Increased, pulmonary edema	Mar 12, 2025	Mar 24, 2025	1 AOP 573: Inhibition, cytochrome oxidase leads to Increased, pulmonary edema
3508	1825: Increase, Cell death	2317: Loss of olfactory function	Mar 13, 2025	Mar 25, 2025	1 AOP 574: Inhibition, cytochrome oxidase leads to Loss of olfactory function
3765	1825: Increase, Cell death	1097: Occurrence, renal proximal tubular necrosis	Mar 29, 2026	Mar 29, 2026	1 AOP 472: DNA adduct formation leading to kidney failure
1712	1505: Cell cycle disruption	1262: Apoptosis	Jan 21, 2018	Jul 28, 2021	1 AOP 212: Histone deacetylase inhibition leading to testicular atrophy
2791	1505: Cell cycle disruption	752: Altered, Meiotic chromosome dynamics	Oct 25, 2022	Oct 25, 2022	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
3363	1505: Cell cycle disruption	1821: Decrease, Cell proliferation	Oct 8, 2024	Jun 23, 2026	4 AOPs 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption 324: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption
3662	1505: Cell cycle disruption	2266: Demyelination, increased	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
3809	2432: Cell cycle arrest	2439: Increase, Telomere attrition	Jul 9, 2026	Jul 9, 2026	1 AOP 645: Binding and activation of AhR lead to cardiovascular aging
2112	1779: Increase, Casp transcription (F3)	1780: Increase, Oocyte apoptosis (F3)	Apr 30, 2020	Apr 30, 2020	1 AOP 340: DNA methyltransferase inhibition leading to transgenerational effects (1)
2116	1779: Increase, Casp transcription (F3)	1783: Increase, Ovarian somatic cell apoptosis (F3)	Apr 30, 2020	Apr 30, 2020	1 AOP 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
2103	1774: Increase, Casp transcription	1775: Increase, Oocyte apoptosis	Apr 30, 2020	Apr 30, 2020	2 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 338: DNA methyltransferase inhibition leading to population decline (3)
2105	1774: Increase, Casp transcription	1776: Increase, Ovarian somatic cell apoptosis	Apr 30, 2020	Apr 30, 2020	1 AOP 337: DNA methyltransferase inhibition leading to population decline (2)
3175	2084: Increase, Cardiac remodelling	2215: Decrease LV function	Apr 3, 2024	Apr 3, 2024	1 AOP 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
60	50: Increase, Ca++ (intracellular)	178: Mitochondrial electron transport chain, disrupted	Nov 29, 2016	Dec 3, 2016	1 AOP 26: Calcium-mediated neuronal ROS production and energy imbalance
2845	2090: Bone Remodeling	2091: Bone Loss	Jan 25, 2023	Aug 9, 2024	1 AOP 482: Deposition of energy leading to occurrence of bone loss
2741	2048: Increase, Body volume of female adults	2050: Increase, developmental abnormalities	Aug 28, 2022	Aug 28, 2022	1 AOP 465: Alcohol dehydrogenase leading to reproductive dysfunction
2092	1769: Increase, Body fluid overload	350: Increase, Mortality	Apr 30, 2020	Apr 30, 2020	1 AOP 327: Excessive reactive oxygen species production leading to mortality (1)
2236	401: Increase, Biliary excretion TH glucuronide	281: T4 in serum, Decreased	Dec 9, 2020	Dec 9, 2020	None
1484	1372: Increase, bicarbonate	1380: Activate, mucosal defense	Apr 17, 2017	Apr 17, 2017	1 AOP 217: Gastric ulcer formation
1469	1365: Increase, Apoptosis	1366: Decrease, Oogenesis	Apr 15, 2017	Apr 15, 2017	None

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