AOP-Wiki

API

All Key Events

Showing 876 to 900 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1522	Inhibition, Chitin synthase 1 Short Name Inhibition, CHS-1	1	Molecular	May 24, 2018	Feb 24, 2021	2 AOPs 360: Chitin synthase 1 inhibition leading to mortality 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
1521	Decrease, Growth Short Name Decrease, Growth	1	Individual	May 24, 2018	Jul 6, 2022	26 AOPs 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2) 286: Mitochondrial complex III antagonism leading to growth inhibition (1) 287: Mitochondrial complex III antagonism leading to growth inhibition (2) 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants 265: Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity 267: Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion 268: Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin 331: Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 598: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell proliferation 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition 324: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption 325: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death 326: Reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation 332: Reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation 333: Reactive oxygen species leading to growth inhibition via protein oxidation and cell death
1519	Glycolysis Short Name Glycolysis	0	Cellular	May 24, 2018	May 24, 2018	None
1517	Decrease, Photosystem II activity Short Name Decrease, PSII activity	0	Molecular	May 24, 2018	Oct 7, 2020	None
1516	Increase, D1 protein antagonism Short Name Increase, D1 protein antagonism	0	Molecular	May 24, 2018	Oct 7, 2020	None
1515	Spermatocyte depletion Short Name Spermatocyte depletion	1	Tissue	May 2, 2018	Jul 28, 2021	212: Histone deacetylase inhibition leading to testicular atrophy
1514	Neurodegeneration Short Name Neurodegeneration	0	Organ	Apr 4, 2018	Apr 4, 2018	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
1513	General Apoptosis Short Name General Apoptosis	1	Cellular	Apr 4, 2018	Oct 18, 2023	3 AOPs 260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration 505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway 513: Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
1512	Unfolded Protein Response Short Name Unfolded Protein Response	0	Molecular	Apr 4, 2018	Sep 14, 2023	3 AOPs 260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration 285: Inhibition of N-linked glycosylation leads to liver injury 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
1511	Lipid Peroxidation Short Name Lipid Peroxidation	0	Molecular	Apr 4, 2018	Apr 4, 2018	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
1509	Protein Adduct Formation Short Name Protein Adduct Formation	0	Molecular	Mar 26, 2018	Mar 26, 2018	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
1508	CYP2E1 Activation Short Name CYP2E1 Activation	0	Molecular	Mar 26, 2018	Apr 9, 2018	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
1507	Activation of PPARγ Short Name Activation of PPARγ	0	Molecular	Mar 18, 2018	Mar 18, 2018	646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
1506	Testicular atrophy Short Name Testicular atrophy	1	Organ	Jan 21, 2018	Jul 1, 2021	212: Histone deacetylase inhibition leading to testicular atrophy
1505	Increase, Cell cycle disruption Short Name Cell cycle disruption	1	Cellular	Jan 21, 2018	May 19, 2026	8 AOPs 212: Histone deacetylase inhibition leading to testicular atrophy 393: AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation 396: Deposition of ionizing energy leads to population decline via impaired meiosis 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function 324: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption
1504	p21 (CDKN1A) expression, increase Short Name p21 (CDKN1A) expression, increase	1	Cellular	Jan 21, 2018	Nov 26, 2018	None
1503	Histone acetylation, increase Short Name Histone acetylation, increase	1	Cellular	Jan 21, 2018	Jul 28, 2021	2 AOPs 212: Histone deacetylase inhibition leading to testicular atrophy 275: Histone deacetylase inhibition leads to neural tube defects
1502	Histone deacetylase inhibition Short Name Histone deacetylase inhibition	1	Molecular	Jan 21, 2018	Jul 14, 2022	4 AOPs 212: Histone deacetylase inhibition leading to testicular atrophy 274: Histone deacetylase inhibition leads to impeded craniofacial development 275: Histone deacetylase inhibition leads to neural tube defects 449: Ceramide synthase inhibition leading to neural tube defects
1501	Increase, Extracellular matrix deposition Short Name Increase, ECM deposition	0	Tissue	Jan 5, 2018	Feb 10, 2026	4 AOPs 383: Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis 414: Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway 415: Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway 494: AhR activation leading to liver fibrosis
1500	Increased, fibroblast proliferation and myofibroblast differentiation Short Name	0	Tissue	Jan 5, 2018	May 17, 2023	173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
1499	Increased, activation of T (T) helper (h) type 2 cells Short Name Activation of Th2 cells	0	Tissue	Jan 3, 2018	May 12, 2023	173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
1498	Loss of alveolar capillary membrane integrity Short Name	0	Tissue	Jan 3, 2018	May 17, 2023	2 AOPs 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 302: Lung surfactant function inhibition leading to decreased lung function
1497	Increased, recruitment of inflammatory cells Short Name Recruitment of inflammatory cells	2	Tissue	Jan 3, 2018	May 12, 2023	8 AOPs 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 303: Frustrated phagocytosis-induced lung cancer 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation 409: Frustrated phagocytosis leads to malignant mesothelioma 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 451: Interaction with lung resident cell membrane components leads to lung cancer 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
1496	Increased, secretion of proinflammatory mediators Short Name Increased proinflammatory mediators	4	Cellular	Jan 2, 2018	Jun 22, 2026	11 AOPs 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation 409: Frustrated phagocytosis leads to malignant mesothelioma 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response 319: Binding to ACE2 leading to lung fibrosis 451: Interaction with lung resident cell membrane components leads to lung cancer 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis via acute phase response
1495	Substance interaction with the lung resident cell membrane components Short Name Interaction with the lung cell membrane	3	Molecular	Jan 2, 2018	Jun 22, 2026	3 AOPs 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 451: Interaction with lung resident cell membrane components leads to lung cancer 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis via acute phase response