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All Key Events

Showing 176 to 200 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

382	Aberrant, Dendritic morphology Short Name Aberrant, Dendritic morphology	1	Cellular	Nov 29, 2016	Sep 16, 2017	13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
383	Reduced, Presynaptic release of glutamate Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
384	Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci Short Name	0		Nov 29, 2016	Nov 29, 2016	None
385	Decrease of synaptogenesis Short Name Synaptogenesis, Decreased	1	Cellular	Nov 29, 2016	Sep 16, 2017	4 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 533: Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
386	Decrease of neuronal network function Short Name Neuronal network function, Decreased	1	Organ	Nov 29, 2016	May 28, 2018	12 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants 501: Excessive iron accumulation leading to neurological disorders 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons 522: Estrogen antagonism leading to increased risk of autism-like behavior 533: Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
387	Binding of agonist, NMDARs Short Name Binding of agonist, NMDARs	0	Molecular	Nov 29, 2016	Nov 29, 2016	None
388	Overactivation, NMDARs Short Name Overactivation, NMDARs	2	Cellular	Nov 29, 2016	Jul 14, 2024	5 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons 471: Neuron defect induced early behavioral change
389	Increased, Intracellular Calcium overload Short Name	1	Cellular	Nov 29, 2016	Jun 26, 2020	7 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons 535: Binding and activation of GPER leading to learning and memory impairments 556: Decreased Na/K ATPase activity leading to heart failure 558: Phosphodiesterase inhibition leading to heart failure
396	Covalent Binding, Protein Short Name Covalent Binding, Protein	1	Molecular	Nov 29, 2016	Nov 5, 2020	2 AOPs 40: Covalent Protein binding leading to Skin Sensitisation 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
397	Response, Keratinocytes Short Name Response, Keratinocytes	0	Cellular	Nov 29, 2016	Nov 29, 2016	None
398	Activation, Dendritic Cells Short Name Activation, Dendritic Cells	2	Cellular	Nov 29, 2016	Dec 3, 2020	2 AOPs 40: Covalent Protein binding leading to Skin Sensitisation 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
401	Increase, Biliary excretion TH glucuronide Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	None
402	Cognitive function, decreased Short Name Cognitive function, decreased	2	Individual	Nov 29, 2016	Jul 25, 2024	15 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 300: Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition 486: Binding to the extracellular protein laminin leading to decreased cognitive function 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition 488: Increased reactive oxygen species production leading to decreased cognitive function 489: Inhibition of voltage-gated sodium channels leading to decreased cognition 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 442: Binding to voltage gate sodium channels during development leads to cognitive impairment 581: Glucocorticoid receptor (GR) activation during development leads to cognitive function (COG) decrease
403	Suppression, Immune system Short Name Suppression, Immune system	1	Individual	Nov 29, 2016	Dec 3, 2016	4 AOPs 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure 85: Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia
405	disrupted, ovarian cycle Short Name disrupted, ovarian cycle	1	Individual	Nov 29, 2016	Dec 17, 2024	3 AOPs 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female 398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia 345: Androgen receptor (AR) antagonism leading to decreased fertility in females
406	decreased, Fertility Short Name decreased, Fertility	2	Individual	Nov 29, 2016	Dec 17, 2024	12 AOPs 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female 51: PPARα activation leading to impaired fertility in adult male rodents 18: PPARα activation in utero leading to impaired fertility in males 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory 396: Deposition of ionizing energy leads to population decline via impaired meiosis 398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress 345: Androgen receptor (AR) antagonism leading to decreased fertility in females 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis 400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility
408	reduction in ovarian granulosa cells, Aromatase (Cyp19a1) Short Name	2	Cellular	Nov 29, 2016	May 28, 2021	7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female
409	Metabolism of AFB1, Production of Reactive Electrophiles Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
413	Reduction, Testosterone synthesis in Leydig cells Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 51: PPARα activation leading to impaired fertility in adult male rodents 18: PPARα activation in utero leading to impaired fertility in males 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
414	Increase, Luteinizing hormone (LH) Short Name Increase, Luteinizing hormone (LH)	1	Cellular	Nov 29, 2016	Sep 16, 2017	51: PPARα activation leading to impaired fertility in adult male rodents
415	Hyperplasia, Leydig cell Short Name Hyperplasia, Leydig cell	1	Cellular	Nov 29, 2016	Sep 27, 2017	51: PPARα activation leading to impaired fertility in adult male rodents
416	Increase proliferation, Leydig cell Short Name Increase proliferation, Leydig cell	1	Cellular	Nov 29, 2016	Sep 16, 2017	51: PPARα activation leading to impaired fertility in adult male rodents
417	skewed, sex ratio Short Name skewed, sex ratio	1	Population	Nov 29, 2016	Dec 3, 2016	52: ER agonism leading to skewed sex ratios due to altered sexual differentiation in males
418	Increased, Vitellogenin synthesis Short Name Increased, Vitellogenin synthesis	1	Cellular	Nov 29, 2016	Sep 16, 2017	53: ER agonism leading to reduced survival due to renal failure
419	Increased, renal vitellogenin deposition Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	53: ER agonism leading to reduced survival due to renal failure