AOP-Wiki

API

All Key Events

Showing 1826 to 1850 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

269	Induction, Sustained Cell Proliferation Short Name Induction, Sustained Cell Proliferation	1	Cellular	Nov 29, 2016	Sep 16, 2017	32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
266	Decrease, Steroidogenic acute regulatory protein (STAR) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	18: PPARα activation in utero leading to impaired fertility in males
265	Increase, Hepatic stellate cell activation Short Name Increase, HSC activation	1	Cellular	Nov 29, 2016	Feb 11, 2026	9 AOPs 38: Protein Alkylation leading to Liver Fibrosis 144: Endocytic lysosomal uptake leading to liver fibrosis 494: AhR activation leading to liver fibrosis 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
264	Activation, SREBP-1c Short Name Activation, SREBP-1c	1	Molecular	Nov 29, 2016	Sep 16, 2017	34: LXR activation leading to hepatic steatosis
261	Binding, SH-/selen-proteins Short Name Binding, SH-/selen-proteins	1	Molecular	Nov 29, 2016	Sep 16, 2017	None
258	Activation, SCD-1 Short Name Activation, SCD-1	1	Molecular	Nov 29, 2016	Sep 16, 2017	34: LXR activation leading to hepatic steatosis
253	N/A, Reproductive failure Short Name N/A, Reproductive failure	1	Individual	Nov 29, 2016	Dec 3, 2016	28: Cyclooxygenase inhibition leading reproductive failure
252	Increase, Renal pathology due to VTG deposition Short Name	1	Organ	Nov 29, 2016	Jun 24, 2024	2 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure
250	Damaging, Red blood cells; hemolysis Short Name Damaging, Red blood cells; hemolysis	1	Cellular	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
246	Increase, RBC congestion in liver Short Name Increase, RBC congestion in liver	2	Organ	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
245	Activation, PXR/SXR Short Name Activation, PXR/SXR	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 11: Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
244	Alkylation, Protein Short Name Alkylation, Protein	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 38: Protein Alkylation leading to Liver Fibrosis 258: Renal protein alkylation leading to kidney toxicity
243	Reduction, Prostaglandin E2 concentration Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	28: Cyclooxygenase inhibition leading reproductive failure
240	Feminisation or incomplete development, Primary and accessory male sex organs Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
239	Activation, Pregnane-X receptor, NR1I2 Short Name Activation, Pregnane-X receptor, NR1I2	1	Molecular	Nov 29, 2016	May 25, 2026	4 AOPs 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 517: Pregnane X Receptor (PXR) activation leads to liver steatosis 545: Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis 548: Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression
238	Induction, Pre-mature molting Short Name Induction, Pre-mature molting	0		Nov 29, 2016	Nov 29, 2016	None
234	Activation, PPARα & PPARγ Short Name Activation, PPARα & PPARγ	0	Molecular	Nov 29, 2016	Dec 3, 2016	None
233	Decreased, PPAR-gamma activation Short Name Decreased, PPAR-gamma activation	1	Molecular	Nov 29, 2016	Oct 30, 2023	2 AOPs 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis 513: Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
232	Decreased, PPAR-beta activation Short Name Decreased, PPAR-beta activation	1	Molecular	Nov 29, 2016	Sep 16, 2017	36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
231	Decreased, PPAR-alpha activation Short Name Decreased, PPAR-alpha activation	1	Molecular	Nov 29, 2016	Sep 16, 2017	36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
228	peroxisome proliferator activated receptor promoter demethylation Short Name demethylation, PPARg promoter	1	Molecular	Nov 29, 2016	Sep 16, 2017	4 AOPs 34: LXR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis 72: Epigenetic modification of PPARG leading to adipogenesis 510: Demethylation of PPAR promotor leading to vascular disrupting effects
227	Activation, PPARα Short Name Activation, PPARα	1	Molecular	Nov 29, 2016	Dec 28, 2020	9 AOPs 18: PPARα activation in utero leading to impaired fertility in males 51: PPARα activation leading to impaired fertility in adult male rodents 61: NFE2L2/FXR activation leading to hepatic steatosis 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone 401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production 614: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor
222	Elimination of (high doses), Posterior cardinal vein Short Name	0		Nov 29, 2016	Nov 29, 2016	None
221	Reduction, Plasma vitellogenin concentrations Short Name	1	Organ	Nov 29, 2016	May 27, 2026	11 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
220	Increase, Plasma vitellogenin concentrations Short Name	1	Organ	Nov 29, 2016	Jun 24, 2024	4 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 53: ER agonism leading to reduced survival due to renal failure 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver