AOP-Wiki

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All Key Events

Showing 51 to 75 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

130	Depletion, GSH Short Name Depletion, GSH	1	Cellular	Nov 29, 2016	Sep 14, 2023	492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress
131	Down Regulation, Gulcose-6-phosphate dehydrogenase Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
134	Increase, Kupffer cell activation Short Name Increase, Kupffer cell activation	1	Cellular	Nov 29, 2016	Feb 11, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
139	N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects Short Name	1	Tissue	Nov 29, 2016	Nov 29, 2016	41: Sustained AhR Activation leading to Rodent Liver Tumours
140	Decreased, HSD17B10 expression Short Name Decreased, HSD17B10 expression	1	Cellular	Nov 29, 2016	Sep 16, 2017	36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
142	Hyperplasia, Hyperplasia Short Name Hyperplasia, Hyperplasia	1	Tissue	Nov 29, 2016	Sep 16, 2017	1: Uncharacterized liver damage leading to hepatocellular carcinoma
145	Induction, IKB inhibitory protein Short Name Induction, IKB inhibitory protein	1	Cellular	Nov 29, 2016	Sep 16, 2017	14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
147	Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307 Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
149	Increase, Inflammation Short Name Increase, Inflammation	1	Cellular	Nov 29, 2016	Feb 28, 2024	8 AOPs 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) 115: Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis 280: α-diketone-induced bronchiolitis obliterans 439: Activation of the AhR leading to metastatic breast cancer 505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway 544: Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation 577: AhR activation leading to endometriosis
151	Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways Short Name	2	Molecular	Nov 29, 2016	Nov 5, 2020	None
152	Suppression, Inflammatory cytokines Short Name Suppression, Inflammatory cytokines	1	Individual	Nov 29, 2016	Dec 3, 2016	14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
155	Inadequate DNA repair Short Name Inadequate DNA repair	1	Cellular	Nov 29, 2016	Mar 8, 2024	11 AOPs 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations 141: Alkylation of DNA leading to cancer 2 139: Alkylation of DNA leading to cancer 1 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer 322: Alkylation of DNA leading to reduced sperm count 397: Bulky DNA adducts leading to mutations 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia 443: DNA damage and mutations leading to Metastatic Breast Cancer 478: Deposition of energy leading to occurrence of cataracts 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage
158	N/A, Interferences with SH-/selen-proteins Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	None
161	Increase, Liver and splenic hemosiderosis Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
164	Induction, Liver “Dysfunctional” Changes by CGA 330050 Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
165	Activation, Long term AHR receptor driven direct and indirect gene expression changes Short Name	1	Cellular	Nov 29, 2016	Dec 2, 2016	41: Sustained AhR Activation leading to Rodent Liver Tumours
166	Decreased, Long-term potentiation (LTP) Short Name Decreased, Long-term potentiation (LTP)	1	Organ	Nov 29, 2016	Sep 16, 2017	26: Calcium-mediated neuronal ROS production and energy imbalance
167	Activation, LXR Short Name Activation, LXR	2	Molecular	Nov 29, 2016	May 21, 2024	3 AOPs 34: LXR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis 518: Liver X Receptor (LXR) activation leads to liver steatosis
168	Decreased, Lymphocytes Short Name Decreased, Lymphocytes	1	Individual	Nov 29, 2016	Dec 3, 2016	14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
169	Disruption, Membrane integrity Short Name Disruption, Membrane integrity	1	Cellular	Nov 29, 2016	Sep 16, 2017	35: Narcosis leading to respiratory failure
173	N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number Short Name	3	Organ	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
177	Increase, Mitochondrial dysfunction Short Name Increase, Mitochondrial dysfunction	1	Cellular	Nov 29, 2016	Feb 11, 2026	40 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 79: Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 144: Endocytic lysosomal uptake leading to liver fibrosis 178: Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure 200: Estrogen receptor activation leading to breast cancer 273: Mitochondrial complex inhibition leading to liver injury 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity 423: Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production 481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases. 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects 256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity 258: Renal protein alkylation leading to kidney toxicity 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 205: AOP from chemical insult to cell death 335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment 362: Immune mediated hepatitis 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome 34: LXR activation leading to hepatic steatosis 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption 587: Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits 588: Inhibition of the mitochondrial complex II of nigro-striatal neurons leads to parkinsonian motor deficits 589: Inhibition of the mitochondrial complex IV of nigro-striatal neurons leads to parkinsonian motor deficits 595: Emerging OPFRS reproductive outcome pathway 622: Calcineurin inhibitor induced nephrotoxicity leading to kidney failure 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction
178	Mitochondrial electron transport chain, disrupted Short Name	1	Cellular	Nov 29, 2016	Jan 7, 2026	4 AOPs 26: Calcium-mediated neuronal ROS production and energy imbalance 284: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity. 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
179	Decrease, Fatty acid beta-oxidation Short Name Decrease, Fatty acid β-oxidation	1	Cellular	Nov 29, 2016	May 23, 2025	7 AOPs 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome 529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation
183	Abnormal, Morphogenesis Short Name Abnormal, Morphogenesis	0		Nov 29, 2016	Nov 29, 2016	None