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All Key Events

Showing 1276 to 1300 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1106	Occurrence, cardiac arrhythmia Short Name Occurrence, cardiac arrhythmia	1	Organ	Nov 29, 2016	Sep 16, 2017	8 AOPs 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality 551: Increased Muscarinic M2 Receptor leading to Arrhythmia 554: β-adrenergic receptor agonists leading to arrhythmias. 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias 560: Inhibition of Funny current (If) leading to Arrhythmias 562: HCN Channel Inhibition leading to Arrhythmias
1105	Occurrence, renal ischemia Short Name Occurrence, renal ischemia	1	Tissue	Nov 29, 2016	Dec 3, 2016	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
1104	Decreased, Prostaglandin F2alpha concentration, plasma Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
1103	Inhibition, Cyclooxygenase 1 activity Short Name Inhibition, Cyclooxygenase 1 activity	1	Molecular	Nov 29, 2016	Dec 3, 2016	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
1102	Occurrence, tophi (urate) deposition Short Name Occurrence, tophi (urate) deposition	1	Tissue	Nov 29, 2016	Dec 3, 2016	2 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
1101	Altered, Amphibian metamorphosis Short Name Altered, Amphibian metamorphosis	2	Organ	Nov 29, 2016	Sep 2, 2020	11 AOPs 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis 188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis 189: Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis 190: Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis 191: Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis 192: Pendrin inhibition leading to altered amphibian metamorphosis 193: Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis 194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
1100	Occurrence, cardiac arrthymia Short Name Occurrence, cardiac arrthymia	0		Nov 29, 2016	Nov 29, 2016	None
1098	Increased, blood potassium concentration Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	4 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality 551: Increased Muscarinic M2 Receptor leading to Arrhythmia
1097	Occurrence, renal proximal tubular necrosis Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	5 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways 472: DNA adduct formation leading to kidney failure
1096	Increased, blood uric acid concentration Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
1095	hyperuricemia, Short Name hyperuricemia,	0		Nov 29, 2016	Nov 29, 2016	None
1094	, hyperuricemia Short Name , hyperuricemia	0		Nov 29, 2016	Nov 29, 2016	None
1093	Decreased, Thyroxine (T4) in tissues Short Name Decreased, Thyroxine (T4) in tissues	2	Tissue	Nov 29, 2016	Sep 3, 2020	None
1092	Pulmonary Fibrosis, Short Name Pulmonary Fibrosis,	0		Nov 29, 2016	Nov 29, 2016	None
1091	Physical and/or chemical interaction with cellular components, Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1090	Increased, mesotheliomas Short Name Increased, mesotheliomas	1	Tissue	Nov 29, 2016	Dec 3, 2016	2 AOPs 171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. 409: Frustrated phagocytosis leads to malignant mesothelioma
1089	Increased, Cell Proliferation (mesothelium) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
1087	Increased, inflammation Short Name Increased, inflammation	1	Cellular	Nov 29, 2016	Dec 3, 2016	171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
1086	persistent, cytotoxicity (pleura or peritoneum) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
1085	Increased, hyperplasia (mammary gland) Short Name Increased, hyperplasia (mammary gland)	1	Tissue	Nov 29, 2016	Sep 16, 2017	170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1084	Increased, prolactin secretion Short Name Increased, prolactin secretion	1	Tissue	Nov 29, 2016	Dec 3, 2016	170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1083	Decreased, Dopaminergic activity Short Name Decreased, Dopaminergic activity	1	Cellular	Nov 29, 2016	Dec 3, 2016	170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1082	Increased, adenomas (pituitary) Short Name Increased, adenomas (pituitary)	1	Tissue	Nov 29, 2016	Sep 16, 2017	169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1081	Increased, lactotroph hyperplasia and hypertrophy Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1080	Increased, latency period Short Name Increased, latency period	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat