AOP-Wiki

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All Key Events

Showing 1876 to 1900 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

161	Increase, Liver and splenic hemosiderosis Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
158	N/A, Interferences with SH-/selen-proteins Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	None
155	Inadequate DNA repair Short Name Inadequate DNA repair	1	Cellular	Nov 29, 2016	Mar 8, 2024	14 AOPs 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations 141: Alkylation of DNA leading to cancer 2 139: Alkylation of DNA leading to cancer 1 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer 322: Alkylation of DNA leading to decreased sperm count 397: Bulky DNA adducts leading to mutations 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia 443: DNA damage and mutations leading to Metastatic Breast Cancer 478: Deposition of energy leading to occurrence of cataracts 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage 324: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption 325: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death 644: Bulky DNA adducts leading to chromosomal aberrations and mutations
152	Suppression, Inflammatory cytokines Short Name Suppression, Inflammatory cytokines	1	Individual	Nov 29, 2016	Dec 3, 2016	14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
151	Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways Short Name	2	Molecular	Nov 29, 2016	Nov 5, 2020	None
149	Increase, Inflammation Short Name Increase, Inflammation	1	Cellular	Nov 29, 2016	Feb 28, 2024	10 AOPs 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) 115: Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis 280: α-diketone-induced bronchiolitis obliterans 439: Activation of the AhR leading to metastatic breast cancer 505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway 544: Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation 577: AhR activation leading to endometriosis 472: DNA adduct formation leading to kidney failure 645: Binding and activation of AhR lead to cardiovascular aging
147	Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307 Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
145	Induction, IKB inhibitory protein Short Name Induction, IKB inhibitory protein	1	Cellular	Nov 29, 2016	Sep 16, 2017	14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
142	Hyperplasia, Hyperplasia Short Name Hyperplasia, Hyperplasia	1	Tissue	Nov 29, 2016	Sep 16, 2017	1: Uncharacterized liver damage leading to hepatocellular carcinoma
140	Decreased, HSD17B10 expression Short Name Decreased, HSD17B10 expression	1	Cellular	Nov 29, 2016	Sep 16, 2017	36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
139	N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects Short Name	1	Tissue	Nov 29, 2016	Nov 29, 2016	41: Sustained AhR Activation leading to Rodent Liver Tumours
134	Increase, Kupffer cell activation Short Name Increase, Kupffer cell activation	1	Cellular	Nov 29, 2016	Feb 11, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
131	Down Regulation, Gulcose-6-phosphate dehydrogenase Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
130	Depletion, GSH Short Name Depletion, GSH	1	Cellular	Nov 29, 2016	Sep 14, 2023	492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress
129	Reduction, Gonadotropins, circulating concentrations Short Name	2	Organ	Nov 29, 2016	May 9, 2018	23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
122	Increase, Glucocorticoid receptor activation Short Name Increase, GR activation	1	Molecular	Nov 29, 2016	Feb 12, 2026	11 AOPs 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility 214: Network of SSRIs (selective serotonin reuptake inhibitors) 318: Glucocorticoid Receptor activation leading to hepatic steatosis 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration 581: Glucocorticoid receptor (GR) activation during development leads to cognitive function (COG) decrease 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
119	N/A, Gap Short Name N/A, Gap	1	Tissue	Nov 29, 2016	Sep 16, 2017	28: Cyclooxygenase inhibition leading reproductive failure
118	Formation, Formation of hemoglobin adducts Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
116	Activation, FAS Short Name Activation, FAS	1	Molecular	Nov 29, 2016	Sep 16, 2017	34: LXR activation leading to hepatic steatosis
115	Increase, Fatty acid influx Short Name Increase, FA influx	1	Cellular	Nov 29, 2016	Feb 11, 2026	2 AOPs 34: LXR activation leading to hepatic steatosis 517: Pregnane X Receptor (PXR) activation leads to liver steatosis
112	Antagonism, Estrogen receptor Short Name Antagonism, Estrogen receptor	1	Molecular	Nov 29, 2016	Sep 16, 2017	4 AOPs 30: Estrogen receptor antagonism leading to reproductive dysfunction 443: DNA damage and mutations leading to Metastatic Breast Cancer 522: Estrogen antagonism leading to increased risk of autism-like behavior 595: Emerging OPFRS reproductive outcome pathway
111	Agonism, Estrogen receptor Short Name Agonism, Estrogen receptor	2	Molecular	Nov 29, 2016	Sep 11, 2025	8 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 52: ER agonism leading to skewed sex ratios due to altered sexual differentiation in males 53: ER agonism leading to reduced survival due to renal failure 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver 112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) 200: Estrogen receptor activation leading to breast cancer 167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
110	Impairment, Endothelial network Short Name Impairment, Endothelial network	1	Cellular	Nov 29, 2016	Jan 18, 2022	2 AOPs 43: Disruption of VEGFR Signaling Leading to Developmental Defects 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
106	Reduction, Eggshell thickness Short Name Reduction, Eggshell thickness	1	Tissue	Nov 29, 2016	Sep 16, 2017	28: Cyclooxygenase inhibition leading reproductive failure
105	Inhibition, Mitochondrial Electron Transport Chain Complexes Short Name	0	Molecular	Nov 29, 2016	Mar 22, 2023	4 AOPs 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production