AOP-Wiki

API

All Key Events

Showing 926 to 950 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1377	Decrease, leukocyte adherence Short Name Decrease, leukocyte adherence	0	Tissue	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1378	Increase, leukocyte adherence Short Name Increase, leukocyte adherence	0	Tissue	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1379	Activate, leukocyte Short Name Activate, leukocyte	0	Cellular	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1380	Activate, mucosal defense Short Name Activate, mucosal defense	0	Tissue	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1381	Increase, surfactant Short Name Increase, surfactant	0	Molecular	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1382	Decrease, surfactant Short Name Decrease, surfactant	0	Molecular	Apr 17, 2017	Apr 17, 2017	2 AOPs 217: Gastric ulcer formation 229: Helicobacter pylori to gastric ulcer
1383	Activate, phospholipase Short Name Activate, phospholipase	0	Molecular	Apr 17, 2017	Apr 17, 2017	2 AOPs 217: Gastric ulcer formation 229: Helicobacter pylori to gastric ulcer
1384	Increase, ammonium (NH4+) Short Name Increase, ammonium (NH4+)	0	Molecular	Apr 17, 2017	Apr 17, 2017	2 AOPs 217: Gastric ulcer formation 229: Helicobacter pylori to gastric ulcer
1385	Activated, gastric ulcer formation Short Name Activated, gastric ulcer formation	0	Organ	Apr 17, 2017	Jun 2, 2017	4 AOPs 217: Gastric ulcer formation 227: NSAID induced PTGS1 inactivation to gastric ulcer 228: NSAID induced PTGS2 inactivation to gastric ulcer 229: Helicobacter pylori to gastric ulcer
1386	CYP7B activity, inhibition Short Name CYP7B activity, inhibition	0	Molecular	May 2, 2017	May 17, 2017	2 AOPs 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
1387	7α-hydroxypregnenolone synthesis in the brain, decreased Short Name	0	Cellular	May 2, 2017	May 17, 2017	2 AOPs 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
1388	Dopamine release in the brain, decreased Short Name	0	Tissue	May 2, 2017	May 17, 2017	2 AOPs 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
1389	Locomotor activity, decreased Short Name Locomotor activity, decreased	0	Individual	May 2, 2017	May 18, 2017	218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
1390	Sexual behavior, decreased Short Name Sexual behavior, decreased	0	Individual	May 3, 2017	May 17, 2017	219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
1391	Activation of Cyp2E1 Short Name Activation of Cyp2E1	0	Molecular	May 30, 2017	Jun 19, 2021	2 AOPs 220: Cyp2E1 Activation Leading to Liver Cancer 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
1392	Increase, Oxidative Stress Short Name Increase, Oxidative Stress	1	Molecular	May 30, 2017	Feb 11, 2026	66 AOPs 220: Cyp2E1 Activation Leading to Liver Cancer 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 284: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 411: Oxidative stress Leading to Decreased Lung Function 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction 425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants 452: Adverse outcome pathway of PM-induced respiratory toxicity 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 470: Deposition of energy leads to abnormal vascular remodeling 478: Deposition of energy leading to occurrence of cataracts 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress 481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases. 482: Deposition of energy leading to occurrence of bone loss 483: Deposition of Energy Leading to Learning and Memory Impairment 505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway 521: Essential element imbalance leads to reproductive failure via oxidative stress 26: Calcium-mediated neuronal ROS production and energy imbalance 488: Increased reactive oxygen species production leading to decreased cognitive function 396: Deposition of ionizing energy leads to population decline via impaired meiosis 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity 535: Binding and activation of GPER leading to learning and memory impairments 171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality 200: Estrogen receptor activation leading to breast cancer 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome 457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 507: Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 510: Demethylation of PPAR promotor leading to vascular disrupting effects 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects 538: Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways 260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 501: Excessive iron accumulation leading to neurological disorders 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 471: Neuron defect induced early behavioral change 31: Oxidation of iron in hemoglobin leading to hematotoxicity 534: Succinate dehydrogenase (SDH) inhibition leads to cancer through oxidative stress 462: Activation of reactive oxygen species leading the atherosclerosis 324: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and cell death 325: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell growth 326: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell proliferation 331: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 332: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell growth 333: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell proliferation 595: Emerging OPFRS reproductive outcome pathway 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 598: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell proliferation 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption 608: Thyroid Hormone Excess Leading to Reduced, Swimming Performance via Hypomyelination 616: organic UV filter and its Photoproducts reproductive toxicity pathways 622: Calcineurin inhibitor induced nephrotoxicity leading to kidney failure 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress
1393	Hepatocytotoxicity Short Name Hepatocytotoxicity	0	Cellular	May 30, 2017	Jun 19, 2021	220: Cyp2E1 Activation Leading to Liver Cancer
1394	Induction, persistent proliferation/sustained proliferation Short Name Sustained proliferation	4	Cellular	May 30, 2017	Jun 19, 2021	220: Cyp2E1 Activation Leading to Liver Cancer
1395	Liver Cancer Short Name Liver Cancer	0	Organ	May 30, 2017	Jun 19, 2021	220: Cyp2E1 Activation Leading to Liver Cancer
1396	Increased, glucocorticoid receptor activity Short Name	0	Molecular	May 31, 2017	May 31, 2017	2 AOPs 221: Mental stress to depression 222: Mental stress to agitation
1397	Increased, serotonin transporter activity Short Name	0	Cellular	Jun 1, 2017	Jun 1, 2017	3 AOPs 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation
1398	Increased, intracellular serotonin Short Name Increased, intracellular serotonin	0	Cellular	Jun 1, 2017	Jun 1, 2017	3 AOPs 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation
1399	Increased, packaged serotonin Short Name Increased, packaged serotonin	0	Cellular	Jun 1, 2017	Jun 1, 2017	3 AOPs 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation
1400	Increased, synaptic release Short Name Increased, synaptic release	0	Cellular	Jun 1, 2017	Jun 1, 2017	3 AOPs 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation
1401	Decreased, 5-HT3 Short Name Decreased, 5-HT3	0	Tissue	Jun 1, 2017	Jun 1, 2017	223: Serotonin transporter activation to seizure