API

Event: 1760

Key Event Title

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Inhibition, Activin signaling

Short name

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Inhibition, Activin signaling

Biological Context

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Level of Biological Organization
Cellular

Cell term

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Organ term

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Key Event Components

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Process Object Action
activin receptor signaling pathway activin receptor complex decreased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
GR Agonism Leading to Impaired Fin Regeneration KeyEvent

Stressors

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Taxonomic Applicability

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Life Stages

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Life stage Evidence
All life stages High

Sex Applicability

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Term Evidence
Mixed High

Key Event Description

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Activin is a dimeric protein composed of two β subunits. These subunits – either βA or βB – dictate the specific type of activin depending on their pairing. Activins have different function depending on the tissue in which they are acting (Kaneko, 2016)  Activin plays a large role in cancer metastasis, immune response, inflammation and cell migration (Kang & Shyr, 2011). In fish, the activin signaling pathway is involved with the promotion of blastemal cell proliferation in the fin regeneration process (Wehner & Weidinger, 2015).


How It Is Measured or Detected

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Activin signaling can be measured in vitro using the HepG2 cell line (Gray et al., 2003). Activin abundance has been measured in serum using high performance liquid chromotography (HPLC [Sakai et al., 1992]).


Domain of Applicability

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Activin signalling can be found in many different tissue types of different species. The function of activin signalling is dependent on the tissue type (Kaneko, 2016). 


References

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Gray PC, Harrison CA, Vale W. 2003. Cripto forms a complex with activin and type II activin receptors and can block activin signaling. Proceedings of the National Academy of Sciences of the United States of America 100(9):5193-5198. www.pnas.org/cgi/doi/10.1073/pnas.0531290100

Kaneko H, 2016. Handbook of Hormones: Pages 295-297, e33B-2.

Kang HY, Shyr CR. 2011. Activins and Cell Migration. Vitamins and Hormons 85: 129-48. doi: 10.1016/B978-0-12-385961-7.00007-X.

Sakai R, Shiozaki M, Tabuchi M, Eto Y. 1992. The measurement of activin/EDF in mouse serum: Evidence for extragonadal production. Biochemical And Biophysical Research Communications 188(2):921-926. https://doi.org/10.1016/0006-291X(92)91143-E

Wehner D, Weidinger G. 2015. Signaling networks organizing regenerative growth of the zebrafish fin. Trends in Genetics 31 (6):336-343. http://dx.doi.org/10.1016/j.tig.2015.03.012