AOP-Wiki

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All Key Events

Showing 26 to 50 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

60	Induction, Chitin degradation and resorption Short Name	0		Nov 29, 2016	Nov 29, 2016	None
64	Reduction, Ionotropic GABA receptor chloride channel conductance Short Name	1	Cellular	Nov 29, 2016	Feb 6, 2018	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
66	Activation, ChREBP Short Name Activation, ChREBP	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 34: LXR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis
68	Increase, Collagen accumulation Short Name Increase, Collagen accumulation	1	Tissue	Nov 29, 2016	Feb 11, 2026	12 AOPs 38: Protein Alkylation leading to Liver Fibrosis 241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis 144: Endocytic lysosomal uptake leading to liver fibrosis 319: Binding to ACE2 leading to lung fibrosis 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
75	N/A, Covalent binding to protein, possibly lysine residue Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	None
77	Production, Critical Metabolites (CGA 330050 and CGA 265307) Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
78	Reduction, Cumulative fecundity and spawning Short Name	1	Individual	Nov 29, 2016	Mar 20, 2017	17 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
79	Inhibition, Cyclooxygenase activity Short Name Inhibition, Cyclooxygenase activity	2	Molecular	Nov 29, 2016	Sep 16, 2017	6 AOPs 28: Cyclooxygenase inhibition leading reproductive failure 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint 63: Cyclooxygenase inhibition leading to reproductive dysfunction 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
80	Up Regulation, CYP1A1 Short Name Up Regulation, CYP1A1	1	Molecular	Nov 29, 2016	Sep 16, 2017	57: AhR activation leading to hepatic steatosis
84	Up Regulation, CYP1B1 Short Name Up Regulation, CYP1B1	0	Molecular	Nov 29, 2016	Dec 3, 2016	None
87	Release, Cytokine Short Name Release, Cytokine	1	Cellular	Nov 29, 2016	Sep 16, 2017	4 AOPs 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) 303: Frustrated phagocytosis-induced lung cancer 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 412: Endothelial cell dysfunction leading to thromboinflammation
89	Synthesis, De Novo Fatty Acid (FA) Short Name Synthesis, De Novo Fatty Acid (FA)	1	Cellular	Nov 29, 2016	Mar 29, 2024	2 AOPs 34: LXR activation leading to hepatic steatosis 518: Liver X Receptor (LXR) activation leads to liver steatosis
97	Alkylation, DNA Short Name Alkylation, DNA	1	Molecular	Nov 29, 2016	Sep 16, 2017	4 AOPs 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations 139: Alkylation of DNA leading to cancer 1 141: Alkylation of DNA leading to cancer 2 322: Alkylation of DNA leading to reduced sperm count
103	Increase, Ecdysone receptor hyperactivation Short Name Increase, EcR hyperactivation	1	Molecular	Nov 29, 2016	Sep 29, 2025	2 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
105	Inhibition, Mitochondrial Electron Transport Chain Complexes Short Name	0	Molecular	Nov 29, 2016	Mar 22, 2023	4 AOPs 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production
106	Reduction, Eggshell thickness Short Name Reduction, Eggshell thickness	1	Tissue	Nov 29, 2016	Sep 16, 2017	28: Cyclooxygenase inhibition leading reproductive failure
110	Impairment, Endothelial network Short Name Impairment, Endothelial network	1	Cellular	Nov 29, 2016	Jan 18, 2022	2 AOPs 43: Disruption of VEGFR Signaling Leading to Developmental Defects 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
111	Agonism, Estrogen receptor Short Name Agonism, Estrogen receptor	2	Molecular	Nov 29, 2016	Sep 11, 2025	8 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 52: ER agonism leading to skewed sex ratios due to altered sexual differentiation in males 53: ER agonism leading to reduced survival due to renal failure 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver 112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) 200: Estrogen receptor activation leading to breast cancer 167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
112	Antagonism, Estrogen receptor Short Name Antagonism, Estrogen receptor	1	Molecular	Nov 29, 2016	Sep 16, 2017	4 AOPs 30: Estrogen receptor antagonism leading to reproductive dysfunction 443: DNA damage and mutations leading to Metastatic Breast Cancer 522: Estrogen antagonism leading to increased risk of autism-like behavior 595: Emerging OPFRS reproductive outcome pathway
115	Increase, Fatty acid influx Short Name Increase, FA influx	1	Cellular	Nov 29, 2016	Feb 11, 2026	2 AOPs 34: LXR activation leading to hepatic steatosis 517: Pregnane X Receptor (PXR) activation leads to liver steatosis
116	Activation, FAS Short Name Activation, FAS	1	Molecular	Nov 29, 2016	Sep 16, 2017	34: LXR activation leading to hepatic steatosis
118	Formation, Formation of hemoglobin adducts Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
119	N/A, Gap Short Name N/A, Gap	1	Tissue	Nov 29, 2016	Sep 16, 2017	28: Cyclooxygenase inhibition leading reproductive failure
122	Increase, Glucocorticoid receptor activation Short Name Increase, GR activation	1	Molecular	Nov 29, 2016	Feb 12, 2026	11 AOPs 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility 214: Network of SSRIs (selective serotonin reuptake inhibitors) 318: Glucocorticoid Receptor activation leading to hepatic steatosis 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration 581: Glucocorticoid receptor (GR) activation during development leads to cognitive function (COG) decrease 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
129	Reduction, Gonadotropins, circulating concentrations Short Name	2	Organ	Nov 29, 2016	May 9, 2018	23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)