Key Event Title
|Level of Biological Organization|
Key Event Components
|gene expression||teratocarcinoma-derived growth factor 1||increased|
Key Event Overview
AOPs Including This Key Event
|AOP Name||Role of event in AOP|
|GR Agonism Leading to Impaired Fin Regeneration||KeyEvent|
Key Event Description
Cripto-1 is responsible for growth factor activity, as well as activin binding on the cell membrane. Cripto-1 may also be referred to as teratocarcinoma-derived growth factor 1, tdgf1, or one-eyed pinhead protein, depending on the species (Uniprot).
How It Is Measured or Detected
Cripto-1 transcripts can be measured via quantitative real-time PCR (Sengupta et al., 2012; Garland et al., 2019).
Domain of Applicability
Cripto-1 has been measured in different vertebrates with a similar function (Uniprot; see above links)
Garland MA, Sengupta S, Mathew LK, Truong L, Jong ED, Piersma AH, Du JL, Tanguay RL. 2019. Glucocorticoid receptor-dependent induction of cripto-1 (one-eyed pinhead) inhibits zebrafish caudal fin regeneration. Toxicology Reports 6:529-537. https://doi.org/10.1016/j.toxrep.2019.05.013