API

Event: 1759

Key Event Title

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Increase, Cripto-1 expression

Short name

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Increase, Cripto-1 expression

Biological Context

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Level of Biological Organization
Cellular

Cell term

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Organ term

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Key Event Components

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Process Object Action
gene expression teratocarcinoma-derived growth factor 1 increased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
GR Agonism Leading to Impaired Fin Regeneration KeyEvent

Stressors

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Taxonomic Applicability

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Term Scientific Term Evidence Link
zebrafish Danio rerio Moderate NCBI

Life Stages

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Life stage Evidence
larvae Moderate

Sex Applicability

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Term Evidence
Mixed

Key Event Description

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Cripto-1 is responsible for growth factor activity, as well as activin binding on the cell membrane.  Cripto-1  may also be referred to as teratocarcinoma-derived growth factor 1, tdgf1, or one-eyed pinhead protein, depending on the species (Uniprot). The cripto-1 protein binds to TGF-B and Activin receptors as a co-receptor which mediates signalling (Ravisankar et al., 2011). 

Uniprot ID


How It Is Measured or Detected

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Cripto-1 transcripts can be measured via quantitative real-time PCR (Sengupta et al., 2012; Garland et al., 2019).


Domain of Applicability

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  • Cripto-1 has been measured in different vertebrates with a similar function (Uniprot; see above links)
  • The EGF and CFC regions of the protein are highly conserved cross species and provide similar function. However there is fuctional differentiation in mammals compared to that of other species (Ravisankar et al., 2011). 

References

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Garland MA, Sengupta S, Mathew LK, Truong L, Jong ED, Piersma AH, Du JL, Tanguay RL. 2019. Glucocorticoid receptor-dependent induction of cripto-1 (one-eyed pinhead) inhibits zebrafish caudal fin regeneration. Toxicology Reports 6:529-537. https://doi.org/10.1016/j.toxrep.2019.05.013

Ravisankar V, Signh TP, Manoj N. 2011. Molecular evolution of the EGF-CFC protein family. Gene, 428:43-50. doi:10.1016/j.gene.2011.05.007