API

Event: 1759

Key Event Title

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Increase, Cripto-1 expression

Short name

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Increase, Cripto-1 expression

Biological Context

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Level of Biological Organization
Cellular

Cell term

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Organ term

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Key Event Components

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Process Object Action
gene expression teratocarcinoma-derived growth factor 1 increased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
GR Agonism Leading to Impaired Fin Regeneration KeyEvent

Stressors

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Taxonomic Applicability

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Term Scientific Term Evidence Link
zebrafish Danio rerio Moderate NCBI

Life Stages

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Life stage Evidence
larvae Moderate

Sex Applicability

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Term Evidence
Mixed

Key Event Description

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Cripto-1 is responsible for growth factor activity, as well as activin binding on the cell membrane.  Cripto-1  may also be referred to as teratocarcinoma-derived growth factor 1, tdgf1, or one-eyed pinhead protein, depending on the species (Uniprot).

Uniprot ID


How It Is Measured or Detected

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Cripto-1 transcripts can be measured via quantitative real-time PCR (Sengupta et al., 2012; Garland et al., 2019).


Domain of Applicability

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Cripto-1 has been measured in different vertebrates with a similar function (Uniprot; see above links)


References

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Garland MA, Sengupta S, Mathew LK, Truong L, Jong ED, Piersma AH, Du JL, Tanguay RL. 2019. Glucocorticoid receptor-dependent induction of cripto-1 (one-eyed pinhead) inhibits zebrafish caudal fin regeneration. Toxicology Reports 6:529-537. https://doi.org/10.1016/j.toxrep.2019.05.013