Key Event Title
|Level of Biological Organization|
Key Event Components
|gene expression||teratocarcinoma-derived growth factor 1||increased|
Key Event Overview
AOPs Including This Key Event
|AOP Name||Role of event in AOP|
|GR Agonism Leading to Impaired Fin Regeneration||KeyEvent|
Key Event Description
Cripto-1 is responsible for growth factor activity, as well as activin binding on the cell membrane. Cripto-1 may also be referred to as teratocarcinoma-derived growth factor 1, tdgf1, or one-eyed pinhead protein, depending on the species (Uniprot). The cripto-1 protein binds to TGF-B and Activin receptors as a co-receptor which mediates signalling (Ravisankar et al., 2011).
How It Is Measured or Detected
Cripto-1 transcripts can be measured via quantitative real-time PCR (Sengupta et al., 2012; Garland et al., 2019).
Domain of Applicability
- Cripto-1 has been measured in different vertebrates with a similar function (Uniprot; see above links)
- The EGF and CFC regions of the protein are highly conserved cross species and provide similar function. However there is fuctional differentiation in mammals compared to that of other species (Ravisankar et al., 2011).
Garland MA, Sengupta S, Mathew LK, Truong L, Jong ED, Piersma AH, Du JL, Tanguay RL. 2019. Glucocorticoid receptor-dependent induction of cripto-1 (one-eyed pinhead) inhibits zebrafish caudal fin regeneration. Toxicology Reports 6:529-537. https://doi.org/10.1016/j.toxrep.2019.05.013
Ravisankar V, Signh TP, Manoj N. 2011. Molecular evolution of the EGF-CFC protein family. Gene, 428:43-50. doi:10.1016/j.gene.2011.05.007