API

Event: 790

Key Event Title

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Inhibition, 5α-reductase activity

Short name

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Inhibition, 5α-reductase activity

Key Event Component

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Process Object Action
catalytic activity 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (rat) decreased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) MolecularInitiatingEvent

Stressors

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Level of Biological Organization

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Biological Organization
Cellular

Cell term

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Organ term

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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How This Key Event Works

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How It Is Measured or Detected

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Evidence Supporting Taxonomic Applicability

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Evidence for Perturbation by Stressor


Overview for Molecular Initiating Event

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References

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