AOP-Wiki

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All Key Events

Showing 76 to 100 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

185	Increase, Mutations Short Name Increase, Mutations	1	Molecular	Nov 29, 2016	May 15, 2023	10 AOPs 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations 141: Alkylation of DNA leading to cancer 2 139: Alkylation of DNA leading to cancer 1 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer 397: Bulky DNA adducts leading to mutations 443: DNA damage and mutations leading to Metastatic Breast Cancer 478: Deposition of energy leading to occurrence of cataracts
186	Altered, Neuroanatomy Short Name Altered, Neuroanatomy	1	Organ	Nov 29, 2016	Sep 16, 2017	65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
188	Neuroinflammation Short Name Neuroinflammation	2	Tissue	Nov 29, 2016	Jul 15, 2022	9 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms 471: Neuron defect induced early behavioral change 535: Binding and activation of GPER leading to learning and memory impairments
191	Neuronal dysfunction Short Name Neuronal dysfunction	1	Cellular	Nov 29, 2016	Apr 7, 2022	2 AOPs 498: Increased LCN2/iron complex leading to neurological disorders 471: Neuron defect induced early behavioral change
192	Altered, Neurophysiology Short Name Altered, Neurophysiology	1	Organ	Nov 29, 2016	Sep 16, 2017	65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
193	Decreased, Nitric Oxide Short Name Decreased, Nitric Oxide	1	Cellular	Nov 29, 2016	Sep 16, 2017	26: Calcium-mediated neuronal ROS production and energy imbalance
195	Inhibition, NMDARs Short Name Inhibition, NMDARs	1	Molecular	Nov 29, 2016	Sep 16, 2017	3 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 522: Estrogen antagonism leading to increased risk of autism-like behavior
201	Binding of antagonist, NMDA receptors Short Name Binding of antagonist, NMDA receptors	0	Molecular	Nov 29, 2016	Jun 13, 2018	2 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
202	Inhibition, Nuclear factor kappa B (NF-kB) Short Name	1	Molecular	Nov 29, 2016	Mar 2, 2023	5 AOPs 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility 278: IKK complex inhibition leading to liver injury 277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways 618: PPARgamma activation leads to a diminished vaccine response
209	Peptide Oxidation Short Name Peptide Oxidation	1	Molecular	Nov 29, 2016	Nov 13, 2017	4 AOPs 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) 108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) 149: Peptide Oxidation Leading to Hypertension 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
213	N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III) Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	31: Oxidation of iron in hemoglobin leading to hematotoxicity
214	Bile accumulation, Pathological condition Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
216	Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway) Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	57: AhR activation leading to hepatic steatosis
219	Reduction, Plasma 17beta-estradiol concentrations Short Name	1	Organ	Nov 29, 2016	Sep 26, 2017	11 AOPs 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish 153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
220	Increase, Plasma vitellogenin concentrations Short Name	1	Organ	Nov 29, 2016	Jun 24, 2024	4 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 53: ER agonism leading to reduced survival due to renal failure 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver
221	Reduction, Plasma vitellogenin concentrations Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	11 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
222	Elimination of (high doses), Posterior cardinal vein Short Name	0		Nov 29, 2016	Nov 29, 2016	None
227	Activation, PPARα Short Name Activation, PPARα	1	Molecular	Nov 29, 2016	Dec 28, 2020	9 AOPs 18: PPARα activation in utero leading to impaired fertility in males 51: PPARα activation leading to impaired fertility in adult male rodents 61: NFE2L2/FXR activation leading to hepatic steatosis 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone 401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production 614: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor
228	peroxisome proliferator activated receptor promoter demethylation Short Name demethylation, PPARg promoter	1	Molecular	Nov 29, 2016	Sep 16, 2017	4 AOPs 34: LXR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis 72: Epigenetic modification of PPARG leading to adipogenesis 510: Demethylation of PPAR promotor leading to vascular disrupting effects
231	Decreased, PPAR-alpha activation Short Name Decreased, PPAR-alpha activation	1	Molecular	Nov 29, 2016	Sep 16, 2017	36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
232	Decreased, PPAR-beta activation Short Name Decreased, PPAR-beta activation	1	Molecular	Nov 29, 2016	Sep 16, 2017	36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
233	Decreased, PPAR-gamma activation Short Name Decreased, PPAR-gamma activation	1	Molecular	Nov 29, 2016	Oct 30, 2023	2 AOPs 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis 513: Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
234	Activation, PPARα & PPARγ Short Name Activation, PPARα & PPARγ	0	Molecular	Nov 29, 2016	Dec 3, 2016	None
238	Induction, Pre-mature molting Short Name Induction, Pre-mature molting	0		Nov 29, 2016	Nov 29, 2016	None
239	Activation, Pregnane-X receptor, NR1l2 Short Name Activation, Pregnane-X receptor, NR1l2	1	Molecular	Nov 29, 2016	Dec 15, 2025	4 AOPs 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 517: Pregnane X Receptor (PXR) activation leads to liver steatosis 545: Activation, Pregnane-X receptor, NR1l2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis 548: Activation, Pregnane-X receptor, NR1l2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression