AOP-Wiki

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All Key Events

Showing 151 to 175 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

337	N/A, Impairment of reproductive capacity Short Name	1	Individual	Nov 29, 2016	Dec 3, 2016	19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
339	Altered, Larval development Short Name Altered, Larval development	1	Individual	Nov 29, 2016	Dec 3, 2016	29: Estrogen receptor agonism leading to reproductive dysfunction
341	Impairment, Learning and memory Short Name Impairment, Learning and memory	2	Individual	Nov 29, 2016	Jul 26, 2024	22 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 99: Histamine (H2) receptor antagonism leading to reduced survival 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons 483: Deposition of Energy Leading to Learning and Memory Impairment 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory 533: Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory 535: Binding and activation of GPER leading to learning and memory impairments 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
342	Increased, Lethality Short Name Increased, Lethality	0		Nov 29, 2016	Nov 29, 2016	None
344	Increase, Liver fibrosis Short Name Increase, Liver fibrosis	1	Organ	Nov 29, 2016	Feb 11, 2026	10 AOPs 38: Protein Alkylation leading to Liver Fibrosis 144: Endocytic lysosomal uptake leading to liver fibrosis 383: Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis 494: AhR activation leading to liver fibrosis 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
345	N/A, Liver Steatosis Short Name N/A, Liver Steatosis	1	Organ	Nov 29, 2016	Sep 16, 2017	34: LXR activation leading to hepatic steatosis
347	Formation, Liver tumor Short Name Formation, Liver tumor	1	Individual	Nov 29, 2016	Dec 3, 2016	32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
348	Malformation, Male reproductive tract Short Name Malformation, Male reproductive tract	1	Organ	Nov 29, 2016	Sep 16, 2017	18: PPARα activation in utero leading to impaired fertility in males
350	Increase, Mortality Short Name Increase, Mortality	1	Individual	Nov 29, 2016	Oct 26, 2020	16 AOPs 327: Excessive reactive oxygen species production leading to mortality (1) 328: Excessive reactive oxygen species production leading to mortality (2) 329: Excessive reactive oxygen species production leading to mortality (3) 358: Chitinase inhibition leading to mortality 359: Chitobiase inhibition leading to mortality 360: Chitin synthase 1 inhibition leading to mortality 361: Sulfonylureareceptor binding leading to mortality 465: Alcohol dehydrogenase leading to reproductive dysfunction 466: Doda decarboxylase leading to mortality 467: Knickkopf leading to mortality 471: Neuron defect induced early behavioral change 330: Excessive reactive oxygen species production leading to mortality (4) 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
351	Increased Mortality Short Name Increased Mortality	1	Population	Nov 29, 2016	Jul 8, 2022	28 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 96: Axonal sodium channel modulation leading to acute mortality 104: Altered ion channel activity leading impaired heart function 113: Glutamate-gated chloride channel activation leading to acute mortality 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure 410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity. 605: Thyroid Peroxidase Inhibition Leading to Reduced, Swimming Performance via Hypomyelination 608: Thyroid Hormone Excess Leading to Reduced, Swimming Performance via Hypomyelination
352	N/A, Neurodegeneration Short Name N/A, Neurodegeneration	1	Tissue	Nov 29, 2016	Feb 23, 2021	7 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 471: Neuron defect induced early behavioral change
357	Cholestasis, Pathology Short Name Cholestasis, Pathology	1	Individual	Nov 29, 2016	Dec 3, 2016	27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
358	Increase, Pericardial edema Short Name Increase, Pericardial edema	1	Organ	Nov 29, 2016	Sep 16, 2017	None
360	Decrease, Population growth rate Short Name Decrease, Population growth rate	1	Population	Nov 29, 2016	Jan 3, 2023	61 AOPs 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 25: Aromatase inhibition leading to reproductive dysfunction 29: Estrogen receptor agonism leading to reproductive dysfunction 30: Estrogen receptor antagonism leading to reproductive dysfunction 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 63: Cyclooxygenase inhibition leading to reproductive dysfunction 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint 292: Inhibition of tyrosinase leads to decreased population in fish 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 16: Acetylcholinesterase inhibition leading to acute mortality 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 338: DNA methyltransferase inhibition leading to population decline (3) 339: DNA methyltransferase inhibition leading to population decline (4) 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2) 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 297: Inhibition of retinaldehyde dehydrogenase leads to population decline 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory 376: Androgen receptor agonism leading to male-biased sex ratio 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 388: Deposition of ionising energy leading to population decline via programmed cell death 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) 410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity. 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis 605: Thyroid Peroxidase Inhibition Leading to Reduced, Swimming Performance via Hypomyelination 608: Thyroid Hormone Excess Leading to Reduced, Swimming Performance via Hypomyelination
361	Decline, Population Short Name Decline, Population	1	Population	Nov 29, 2016	Dec 3, 2016	201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
363	Altered, Reproductive behaviour Short Name Altered, Reproductive behaviour	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 616: organic UV filter and its Photoproducts reproductive toxicity pathways
364	Impaired development of, Reproductive organs Short Name	1	Individual	Nov 29, 2016	Dec 3, 2016	3 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver 616: organic UV filter and its Photoproducts reproductive toxicity pathways
366	Increased, Structural malformations Short Name Increased, Structural malformations	0		Nov 29, 2016	Nov 29, 2016	None
369	Uroporphyria Short Name Uroporphyria	1	Individual	Nov 29, 2016	May 7, 2018	131: Aryl hydrocarbon receptor activation leading to uroporphyria
373	Formation, Pro-mutagenic DNA Adducts Short Name Formation, Pro-mutagenic DNA Adducts	1	Molecular	Nov 29, 2016	Sep 16, 2017	46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
376	Increased, Induced Mutations in Critical Genes Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
377	Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered Hepatic Foci (AHF)) Short Name	0		Nov 29, 2016	Nov 29, 2016	None
378	Tumorigenesis, Hepatocellular carcinoma Short Name Tumorigenesis, Hepatocellular carcinoma	1	Individual	Nov 29, 2016	Nov 29, 2016	46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
380	Activation, Pre-MIE: Metabolism of AFB1 Short Name Activation, Pre-MIE: Metabolism of AFB1	0	Molecular	Nov 29, 2016	Nov 29, 2016	None
381	Reduced levels of BDNF Short Name BDNF, Reduced	2	Molecular	Nov 29, 2016	Apr 4, 2019	5 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 375: test AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function